Gene

c3b.1

ID
ZDB-GENE-030131-2211
Name
complement component c3b, tandem duplicate 1
Symbol
c3b.1 Nomenclature History
Previous Names
  • c3.7 (1)
  • si:dkey-21e7.2
  • wu:fb99g02
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have endopeptidase inhibitor activity. Predicted to localize to extracellular space. Is expressed in brain; gill; liver; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; and sickle cell anemia. Orthologous to human C3 (complement C3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Forn-CunĂ­ et al., 2014
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With c3b.1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
age related macular degeneration 9 Alliance {Macular degeneration, age-related, 9} 611378
complement component 3 deficiency Alliance C3 deficiency 613779
{Hemolytic uremic syndrome, atypical, susceptibility to, 5} 612925
Associated With c3b.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000020 Anaphylatoxin/fibulin
Domain IPR001134 Netrin domain
Domain IPR001599 Alpha-2-macroglobulin
Domain IPR002890 Macroglobulin domain
Domain IPR009048 Alpha-macroglobulin, receptor-binding
Domain IPR011625 Alpha-2-macroglobulin, bait region domain
Domain IPR011626 Alpha-macroglobulin-like, TED domain
Domain IPR018933 Netrin module, non-TIMP type
Domain IPR040839 Macroglobulin domain MG4
Domain IPR041425 Complement C3/4/5, macroglobulin domain MG1
Domain IPR041555 Macroglobulin domain MG3
Family IPR035711 Complement C3-like
Homologous_superfamily IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR018081 Anaphylatoxin, complement system
Homologous_superfamily IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
Domain Details Per Protein
Protein Length Alpha-2-macroglobulin Alpha-2-macroglobulin, bait region domain Alpha-macroglobulin-like, TED domain Alpha-macroglobulin, receptor-binding Alpha-macroglobulin, receptor-binding domain superfamily Anaphylatoxin, complement system Anaphylatoxin/fibulin Complement C3/4/5, macroglobulin domain MG1 Complement C3-like Immunoglobulin-like fold Macroglobulin domain Macroglobulin domain MG3 Macroglobulin domain MG4 Netrin domain Netrin module, non-TIMP type Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:A5PMP6 1680
UniProtKB:A0A0N4SU63 1681
UniProtKB:A0A0N4STW3 1598
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations