ZFIN ID: ZDB-GENE-030131-2207
Gene Name: zinc finger, C4H2 domain containing
Gene Symbol: zc4h2    Nomenclature History

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Previous Names: un-named hi2729b, unm hi2729b, wu:fb99f08, zgc:63849

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity. Involved in generation of neurons and neuromuscular junction development. Localizes to nucleus. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Miles-Carpenter syndrome. Orthologous to human ZC4H2 (zinc finger C4H2-type containing).
Genome Resources: Alliance (1),  Gene:323487 (1),  Ensembl(GRCz11):ENSDARG00000015314 (1)
GENE EXPRESSION
All Expression Data: 13 figures from 4 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [MGC:63849]
  6 figures (6 images) from Thisse et al., 2004 [IMAGE:6908809]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ck035a Small Deletion Unknown Frameshift TALEN
ck035b Small Deletion Unknown Frameshift TALEN
hi2729bTg Transgenic Insertion Exon 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33577 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38464 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sdu26 Indel Exon 2 Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-zc4h2 1
    MO1-zc4h2 N/A 1
    MO2-zc4h2 N/A 2
    TALEN1-zc4h2 1
    DISEASE ASSOCIATED WITH zc4h2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Miles-Carpenter syndrome Alliance Wieacker-Wolff syndrome 314580
    Wieacker-Wolff syndrome, female-restricted 301041
    DISEASE ASSOCIATED WITH zc4h2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neuromuscular junction development (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA zc4h2-201 (1)    Ensembl 1737
    ncRNA zc4h2-002 (1)    Ensembl 627
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM zc4h2 No data available
    MARKER RELATIONSHIPS
    zc4h2 Contained in: [BAC] DKEY-286F3 (1) (order this)
    zc4h2 Encodes: [EST] fb99f08, IMAGE:6908809 (1)
    [cDNA] MGC:63849 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199642 (1) 1710 nt
    Genomic GenBank:CR812469 (1) 162086 nt
    Select Tool
    Polypeptide UniProtKB:Q7T3I0 (1) 224 aa
    Sequence Information (all 14)
    ORTHOLOGY for zc4h2 ( Chr: 5 )
    CITATIONS (35)