ZFIN ID: ZDB-GENE-030131-2172
Gene Name: methionyl aminopeptidase 2b
Gene Symbol: metap2b    Nomenclature History

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Previous Names: metap2, wu:fb98h06, zgc:66250

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity and metalloaminopeptidase activity. Involved in Wnt signaling pathway; definitive hemopoiesis; and hematopoietic stem cell differentiation. Predicted to localize to cytoplasm. Is expressed in several structures, including digestive system; heart tube; hematopoietic system; pronephric duct; and trunk. Orthologous to human METAP2 (methionyl aminopeptidase 2).
Genome Resources: Alliance (1),  Gene:323452 (1),  Ensembl(GRCz11):ENSDARG00000102571 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7159348]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa37982 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa37984 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-metap2b N/A 2
    DISEASE ASSOCIATED WITH metap2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH metap2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Wnt signaling pathway (more)
    Cellular Component cytoplasm (more)
    Molecular Function aminopeptidase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA metap2b-201 (1)    Ensembl 3008
    ncRNA ottdart00000062074 (1)    Ensembl 784
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM metap2b No data available
    MARKER RELATIONSHIPS
    metap2b Contained in: [BAC] CH73-340G20 (1), CH211-112D9 (1)
    metap2b Encodes: [EST] fb98h06, IMAGE:7159348 (1)
    [cDNA] MGC:66250 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199640 (1) 2462 nt
    Genomic GenBank:CU184832 (1) 187294 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IUB7 (1) 476 aa
    Sequence Information (all 16)
    ORTHOLOGY for metap2b ( Chr: 25 )
    CITATIONS (24)