ZFIN ID: ZDB-GENE-030131-2145
Gene Name: filamin A, alpha (actin binding protein 280)
Gene Symbol: flna    Nomenclature History

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Previous Names: fb98b06, fd09g03, wu:fb98b06, wu:fd09g03, wu:fd49a06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have actin binding activity. Human ortholog(s) of this gene implicated in FG syndrome; bone development disease (multiple); heart valve disease (multiple); and periventricular nodular heterotopia. Orthologous to human FLNA (filamin A).
Genome Resources: Alliance (1),  Gene:562529 (1),  Ensembl(GRCz11):ENSDARG00000074201 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17303 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24296 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24297 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24298 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32439 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43949 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43950 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43951 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-flna N/A 1
    MO2-flna N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH flna HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    FG syndrome Alliance ?FG syndrome 2 300321
    frontometaphyseal dysplasia 1 Alliance Frontometaphyseal dysplasia 1 305620
    Melnick-Needles syndrome Alliance Melnick-Needles syndrome 309350
    otopalatodigital syndrome type 1 Alliance Otopalatodigital syndrome, type I 311300
    otopalatodigital syndrome type 2 Alliance Otopalatodigital syndrome, type II 304120
    periventricular nodular heterotopia Alliance Heterotopia, periventricular, 1 300049
    X-linked cardiac valvular dysplasia Alliance Cardiac valvular dysplasia, X-linked 314400
    X-linked chronic idiopathic intestinal pseudo-obstruction Alliance Congenital short bowel syndrome 300048
    Intestinal pseudoobstruction, neuronal 300048
    Terminal osseous dysplasia 300244
    DISEASE ASSOCIATED WITH flna VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Molecular Function actin binding (more)
    GO Terms (all 1)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA flna-202 (1)    Ensembl 8551
    flna-204 (1)    Ensembl 1058
    ncRNA flna-002 (1)    Ensembl 726
    flna-003 (1)    Ensembl 757
    flna-005 (1)    Ensembl 864
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM flna No data available
    MARKER RELATIONSHIPS
    flna Contained in: [BAC] DKEY-93L1 (1) (order this)
    flna Encodes: [EST] fb98b06, fd09g03, fd49a06
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009296770 (1)
    Genomic GenBank:CR352234 (1) 198117 nt
    Select Tool
    Polypeptide UniProtKB:E9QI62 (1) 2553 aa
    Sequence Information (all 55)
    ORTHOLOGY for flna ( Chr: 23 )
    CITATIONS (21)