Gene

setd2

ID

ZDB-GENE-030131-2140

Name

SET domain containing 2, histone lysine methyltransferase

Symbol

setd2 Nomenclature History

Previous Names

fb97h09
wu:fb97h09 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have histone methyltransferase activity (H3-K36 specific). Predicted to be involved in histone H3-K36 trimethylation and regulation of transcription, DNA-templated. Predicted to localize to chromosome and nucleus. Is expressed in central nervous system and intermediate cell mass of mesoderm. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase).

Genome Resources

Note

None

Expression

All Expression Data

2 figures from Sun et al., 2008

Cross-Species Comparison

High Throughput Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With setd2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Luscan-Lumish syndrome	616831

Associated With setd2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001202	WW domain
Domain	IPR001214	SET domain
Domain	IPR003616	Post-SET domain
Domain	IPR006560	AWS domain
Domain	IPR013257	Set2 Rpb1 interacting domain
Homologous_superfamily	IPR036020	WW domain superfamily
Homologous_superfamily	IPR038190	Set2 Rpb1 interacting domain superfamily

Domain Details Per Protein

Protein	Length	AWS domain	Post-SET domain	Set2 Rpb1 interacting domain	Set2 Rpb1 interacting domain superfamily	SET domain	WW domain	WW domain superfamily
UniProtKB:A0A2R8QDW6 InterPro	2735
UniProtKB:A0A2R8Q1Y5 InterPro	2694
UniProtKB:A0A2R8Q6N6 InterPro	2650
UniProtKB:A5XBP8 InterPro	175
UniProtKB:F1QJI9 InterPro	2737
UniProtKB:Q071D9 InterPro	369

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	setd2-201 (1) Ensembl	9903 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Ensembl Gene Tree

Citations