ZFIN ID: ZDB-GENE-030131-2140
Gene Name: SET domain containing 2, histone lysine methyltransferase
Gene Symbol: setd2    Nomenclature History

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Previous Names: fb97h09, wu:fb97h09 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have histone methyltransferase activity (H3-K36 specific). Predicted to be involved in histone H3-K36 trimethylation and regulation of transcription, DNA-templated. Predicted to localize to chromosome and nucleus. Is expressed in central nervous system and intermediate cell mass of mesoderm. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase).
Genome Resources: Alliance (1),  Gene:794199 (1),  Ensembl(GRCz11):ENSDARG00000062244 (2)
GENE EXPRESSION
All Expression Data: 2 figures from Sun et al., 2008
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa678 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9194 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22792 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25011 Point Mutation Unknown Premature Stop ENU
    sa36079 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39086 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42691 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45570 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-setd2 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH setd2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Luscan-Lumish syndrome 616831
    DISEASE ASSOCIATED WITH setd2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chromatin organization (more)
    Cellular Component chromosome (more)
    Molecular Function histone-lysine N-methyltransferase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA setd2-201 (1)    Ensembl 9903
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM setd2 No data available
    MARKER RELATIONSHIPS
    setd2 Contained in: [BAC] CH211-193P21, DKEY-43F15 (1) (order this)
    setd2 Contains: [SNP] rs3728778, rs3728779 (1), rs3728780 (1), rs3728781 (1)
    setd2 Encodes: [EST] fb97h09
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009292184 (1)
    Genomic GenBank:CU138519 (1) 146595 nt
    Select Tool
    Polypeptide UniProtKB:F1QJI9 (1) 2737 aa
    Sequence Information (all 27)
    ORTHOLOGY for setd2 ( Chr: 16 )
    CITATIONS (23)