ZFIN Gene: setd2

ZFIN ID: ZDB-GENE-030131-2140

ZFIN ID: ZDB-GENE-030131-2140

Gene Name:

SET domain containing 2, histone lysine methyltransferase

Gene Symbol:

setd2

Sequence Ontology ID :

SO:0000704

Previous Names:

fb97h09, wu:fb97h09 (1)

Location:

Chr: 16 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have histone-lysine N-methyltransferase activity. Predicted to be involved in histone lysine methylation and regulation of transcription, DNA-templated. Predicted to localize to the ...

GENE EXPRESSION
All Expression Data:	2 figures from Sun et al., 2008
Wild-type Stages, Structures:	Cleavage:2-cell (0.75h-1.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
	central nervous system intermediate cell mass of mesoderm whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa678	Point Mutation	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa9194	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa22792	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa25011	Point Mutation	Unknown	Premature Stop	ENU
sa36079	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa39086	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42691	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa45570	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

MO1-setd2 (1)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH setd2 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
	Luscan-Lumish syndrome	616831

DISEASE ASSOCIATED WITH setd2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	histone lysine methylation (more)
Cellular Component	chromosome (more)
Molecular Function	histone-lysine N-methyltransferase activity (more)

GO Terms (all 5)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001202 (1) InterPro:IPR001214 (1) InterPro:IPR003616 (1) InterPro:IPR006560 (1) InterPro:IPR013257 (1) InterPro:IPR036020 (1) InterPro:IPR038190 (1) InterPro:IPR042294 (1)	PROSITE:PS01159 (1) PROSITE:PS50020 (1) PROSITE:PS50280 (1) PROSITE:PS50868 (1) PROSITE:PS51215 (1)	Pfam:PF00397 (1) Pfam:PF00856 (1) Pfam:PF08236 (1) Pfam:PF17907 (1)	EC:2.1.1.43 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	setd2-201 (1)	9903	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Withdrawn Transcripts
mRNA	setd2-002 (1)	854	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	setd2-003 (1)	2756	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM setd2 No data available

MARKER RELATIONSHIPS

setd2Contained in:	[BAC] CH211-193P21 (order this), DKEY-43F15 (1) (order this)
setd2Contains:	[SNP] rs3728778, rs3728779 (1), rs3728780 (1), rs3728781 (1)
setd2Encodes:	[EST] fb97h09

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:XM_009292184 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CU138519 (1)	146595bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1QJI9 (1)	2737aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:162278 (1)

Sequence Information (all 29)

OTHER setd2 GENE PAGES

Alliance (1)

Gene:794199 (1)

VEGA:OTTDARG00000032991 (1)

Ensembl(GRCz11):ENSDARG00000062244 (2)

ORTHOLOGY for setd2 (Chr: 16)

CITATIONS (22)

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