ZFIN Gene: setd2

ZFIN ID: ZDB-GENE-030131-2140

ZFIN ID: ZDB-GENE-030131-2140

Gene Name:

SET domain containing 2, histone lysine methyltransferase

Gene Symbol:

setd2 Nomenclature History

Previous Names:

fb97h09, wu:fb97h09 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 16 Mapping Details/Browsers

Description:

Predicted to have histone methyltransferase activity (H3-K36 specific). Predicted to be involved in histone H3-K36 trimethylation and regulation of transcription, DNA-templated. Predicted to localize to chromosome and nucleus. Is expressed in central nervous system and intermediate cell mass of mesoderm. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase).

Genome Resources:

Alliance (1), Gene:794199 (1), Ensembl(GRCz11):ENSDARG00000062244 (2)

GENE EXPRESSION
All Expression Data:	2 figures from Sun et al., 2008
Wild-type Stages, Structures:	Cleavage:2-cell (0.75h-1.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
	central nervous system intermediate cell mass of mesoderm whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa678	Point Mutation	Unknown	Unknown	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa9194	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa22792	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa25011	Point Mutation	Unknown	Premature Stop	ENU
sa36079	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa39086	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42691	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa45570	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-setd2	N/A	1

PHENOTYPE No data available

DISEASE ASSOCIATED WITH setd2 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Luscan-Lumish syndrome	616831

DISEASE ASSOCIATED WITH setd2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	chromatin organization (more)
Cellular Component	chromosome (more)
Molecular Function	histone-lysine N-methyltransferase activity (more)

GO Terms (all 11)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	setd2-201 (1)	9903	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM setd2 No data available

MARKER RELATIONSHIPS

setd2 Contained in:	[BAC] CH211-193P21, DKEY-43F15 (1) (order this)
setd2 Contains:	[SNP] rs3728778, rs3728779 (1), rs3728780 (1), rs3728781 (1)
setd2 Encodes:	[EST] fb97h09

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_009292184 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CU138519 (1)	146595 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1QJI9 (1)	2737 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 27)

ORTHOLOGY for setd2 ( Chr: 16 )

CITATIONS (23)

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