Gene

sin3ab

ID

ZDB-GENE-030131-2066

Name

SIN3 transcription regulator family member Ab

Symbol

sin3ab Nomenclature History

Previous Names

fb95g11
wu:fb95g11

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of Sin3 complex. Predicted to be active in chromatin. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sin3ab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
chromosome 15q24 deletion syndrome	Alliance	Witteveen-Kolk syndrome	613406

Associated With sin3ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013194	Histone deacetylase interacting domain
Domain	IPR031693	Sin3, C-terminal
Family	IPR037969	Transcriptional regulatory protein Sin3a
Family	IPR039774	Transcriptional regulatory protein Sin3-like
Homologous_superfamily	IPR036600	Paired amphipathic helix superfamily
Repeat	IPR003822	Paired amphipathic helix

Domain Details Per Protein

Protein	Length	Histone deacetylase interacting domain	Paired amphipathic helix	Paired amphipathic helix superfamily	Sin3, C-terminal	Transcriptional regulatory protein Sin3a	Transcriptional regulatory protein Sin3-like
UniProtKB:A0A1L1QZM2 InterPro	204
UniProtKB:E7F0R9 InterPro	1262

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	sin3ab-201 (1) Ensembl	5330 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	sin3ab-202 (1) Ensembl	1598 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	sin3ab-002 (1) Ensembl	687 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations