ZFIN ID: ZDB-GENE-030131-1980
Gene Name: growth arrest-specific 8
Gene Symbol: gas8    Nomenclature History

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Previous Names: wu:fb93e12, zgc:66271

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have Rab GTPase binding activity. Involved in muscle cell development; otolith development; and positive regulation of smoothened signaling pathway. Predicted to localize to Golgi apparatus; ciliary basal body; and microtubule. Is expressed in neural tube; otic placode; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8).
Genome Resources: Alliance (1),  Gene:323260 (1),  Ensembl(GRCz11):ENSDARG00000101431 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66271]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17198 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gas8
    1
    MO1-gas8 N/A 2
    MO2-gas8 N/A 1
    DISEASE ASSOCIATED WITH gas8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary ciliary dyskinesia 33 Alliance Ciliary dyskinesia, primary, 33 616726
    DISEASE ASSOCIATED WITH gas8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process muscle cell development (more)
    Cellular Component ciliary basal body (more)
    Molecular Function microtubule binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gas8-202 (1)    Ensembl 1590
    ncRNA gas8-002 (1)    Ensembl 410
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gas8 No data available
    MARKER RELATIONSHIPS
    gas8 Contained in: [Fosmid] CH1073-94D16 (1), ZFOS-446E12 (1)
    gas8 Encodes: [EST] fb93e12
    [cDNA] MGC:66271 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199634 (1) 1639 nt
    Genomic GenBank:CU570687 (1) 36595 nt
    Select Tool
    Polypeptide UniProtKB:F1QNW4 (1) 475 aa
    Sequence Information (all 13)
    ORTHOLOGY for gas8 ( Chr: 18 )
    CITATIONS (24)