ZFIN ID: ZDB-GENE-030131-1966
Gene Name: capicua transcriptional repressor b
Gene Symbol: cicb    Nomenclature History

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Previous Names: cic, wu:fb93c01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have DNA binding activity. Involved in primitive erythrocyte differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 45. Is expressed in head and hindbrain neural rod. Orthologous to human CIC (capicua transcriptional repressor).
Genome Resources: Alliance (1),  Gene:323246 (1),  Ensembl(GRCz11):ENSDARG00000055502 (2)
GENE EXPRESSION
All Expression Data: Fig. 3 from Chen et al., 2014
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019537Tg Transgenic Insertion Unknown Unknown DNA
sa6414 Point Mutation Unknown Premature Stop ENU
sa11051 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12482 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13638 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13672 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14154 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36055 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cicb N/A 1
    DISEASE ASSOCIATED WITH cicb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant mental retardation 45 Alliance Mental retardation, autosomal dominant 45 617600
    DISEASE ASSOCIATED WITH cicb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process primitive erythrocyte differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR009071 High mobility group box domain
    Domain IPR032147 Domain of unknown function DUF4819
    Homologous_superfamily IPR036910 High mobility group box domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cicb-201 (1)    Ensembl 9811
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cicb No data available
    MARKER RELATIONSHIPS
    cicb Contained in: [BAC] DKEY-165G20 (1) (order this)
    cicb Encodes: [EST] fb93c01
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005173512 (1) 9827 nt
    Genomic GenBank:CR848744 (1) 246497 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q6M9 (1) 2623 aa
    Sequence Information (all 19)
    ORTHOLOGY for cicb ( Chr: 16 )
    CITATIONS (22)