Gene
usp8
- ID
- ZDB-GENE-030131-1949
- Name
- ubiquitin specific peptidase 8
- Symbol
- usp8 Nomenclature History
- Previous Names
-
- wu:fb15f07
- wu:fb92h07
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within regulation of cilium assembly. Predicted to be located in cellular anatomical entity. Predicted to be active in several cellular components, including dendritic spine; midbody; and postsynaptic density. Predicted to be extrinsic component of plasma membrane. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ACTH-secreting pituitary adenoma | Alliance | Pituitary adenoma 4, ACTH-secreting, somatic | 219090 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR001763 | Rhodanese-like domain |
| Domain | IPR015063 | USP8 dimerisation domain |
| Domain | IPR028889 | Ubiquitin specific protease domain |
| Homologous_superfamily | IPR036873 | Rhodanese-like domain superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Rhodanese-like domain | Rhodanese-like domain superfamily | Ubiquitin specific protease, conserved site | Ubiquitin specific protease domain | USP8 dimerisation domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P169
|
1067 | |||||||
|
UniProtKB:A0A8M3ARQ7
|
1066 |
Interactions and Pathways
No data available
Plasmids
No data available