ZFIN ID: ZDB-GENE-030131-1904
Gene Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Gene Symbol: pik3cb    Nomenclature History

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Previous Names: fb92a07, wu:fb92a07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in cell migration; phosphatidylinositol 3-kinase signaling; and phosphatidylinositol metabolic process. Predicted to localize to cytoplasm; phosphatidylinositol 3-kinase complex; and plasma membrane. Human ortholog(s) of this gene implicated in glioblastoma multiforme; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta).
Genome Resources: Alliance (1),  Gene:100002263 (1),  Ensembl(GRCz11):ENSDARG00000075253 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16161 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16592 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42487 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42488 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45529 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pik3cb N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pik3cb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pik3cb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphatidylinositol-mediated signaling (more)
    Cellular Component cytoplasm (more)
    Molecular Function 1-phosphatidylinositol-3-kinase activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pik3cb-202 (1)    Ensembl 5316
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pik3cb No data available
    MARKER RELATIONSHIPS
    pik3cb Contained in: [BAC] CH73-189G16 (1), CH73-232G7 (1), CH211-61A15 (1)
    pik3cb Contains: [SNP] rs3728696 (1)
    pik3cb Encodes: [EST] fb92a07
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005157466 (1) 5210 nt
    Genomic GenBank:CR513781 (1) 158040 nt
    Select Tool
    Polypeptide UniProtKB:E7F251 (1) 1080 aa
    Sequence Information (all 15)
    ORTHOLOGY for pik3cb ( Chr: 15 )
    CITATIONS (22)