ZFIN ID: ZDB-GENE-030131-1826
Gene Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Gene Symbol: ace    Nomenclature History

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Previous Names: fb81h03, si:ch211-124e16.1, wu:fb81h03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have metallopeptidase activity and peptidyl-dipeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to plasma membrane. Is expressed in several structures, including adaxial cell; digestive system; endocrine system; eye; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); hematologic cancer (multiple); lung disease (multiple); and nephritis (multiple). Orthologous to human ACE (angiotensin I converting enzyme).
Genome Resources: Alliance (1),  Gene:565980 (1),  Ensembl(GRCz11):ENSDARG00000079166 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9141 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12049 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17717 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19024 Point Mutation Unknown Splice Site ENU
    sa41956 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ace N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ace HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Renal tubular dysgenesis 267430
    [Angiotensin I-converting enzyme, benign serum increase]
    {Microvascular complications of diabetes 3} 612624
    {Myocardial infarction, susceptibility to}
    {SARS, progression of}
    {Stroke, hemorrhagic} 614519
    DISEASE ASSOCIATED WITH ace VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function carboxypeptidase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ace-201 (1)    Ensembl 4260
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ace No data available
    MARKER RELATIONSHIPS
    ace Contained in: [BAC] CH211-124E16 (1), CH211-271E19 (1)
    ace Encodes: [EST] fb64c02 (1) (order this), fb81h03 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_689244 (1)
    Genomic GenBank:CU459092 (1) 147841 nt
    Select Tool
    Polypeptide UniProtKB:E7FFA5 (1) 1324 aa
    Sequence Information (all 12)
    ORTHOLOGY for ace ( Chr: 12 )
    CITATIONS (29)