ZFIN ID: ZDB-GENE-030131-1819
Gene Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b
Gene Symbol: nfkbiab    Nomenclature History

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Previous Names: Ikbab, nfkbia, wu:fb81f08, zgc:56666 (1), zgc:77616 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypohidrotic ectodermal dysplasia; lung cancer; melanoma; and prostate cancer. Is expressed in EVL; epidermis; lateral line system; vent; and ventricular zone. Orthologous to human NFKBIA (NFKB inhibitor alpha).
Genome Resources: Alliance (1),  Gene:323099 (1),  Ensembl(GRCz11):ENSDARG00000007693 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 5 publications
Directly Submitted Expression Data: 7 figures (9 images) from Thisse et al., 2004 [MGC:56666]
Wild-type Stages, Structures: Cleavage:32-cell (1.75h-2.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18322 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nfkbiab HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Ectodermal dysplasia and immunodeficiency 2 612132
    DISEASE ASSOCIATED WITH nfkbiab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY No data available
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Repeat IPR002110 Ankyrin repeat
    Domain IPR020683 Ankyrin repeat-containing domain
    Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nfkbiab-201 (1)    Ensembl 1354
    ncRNA nfkbiab-002 (1)    Ensembl 768
    nfkbiab-003 (1)    Ensembl 832
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nfkbiab No data available
    MARKER RELATIONSHIPS
    nfkbiab Contained in: [BAC] DKEYP-33B5 (1)
    nfkbiab Encodes: [EST] fb81f08
    [cDNA] MGC:56666, MGC:77616 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199629 (1) 1337 bp
    Genomic GenBank:BX649530 (1) 150656 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8RUD4 (1) 313 aa
    Sequence Information (all 17)
    ORTHOLOGY for nfkbiab ( Chr: 17 )
    CITATIONS (44)