Gene

exosc8

ID

ZDB-GENE-030131-1736

Name

exosome component 8

Symbol

exosc8 Nomenclature History

Previous Names

Opa-interacting protein 2 (3' exoribonuclease family) (1)
wu:fb79a10
zgc:110381

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have AU-rich element binding activity. Involved in axonogenesis; cerebellar Purkinje cell layer structural organization; and myelination. Predicted to localize to cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Is expressed in alar plate midbrain region; immature eye; midbrain; and retina. Orthologous to human EXOSC8 (exosome component 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7157503 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With exosc8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pontocerebellar hypoplasia type 1C	Alliance	Pontocerebellar hypoplasia, type 1C	616081

Associated With exosc8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001247	Exoribonuclease, phosphorolytic domain 1
Domain	IPR015847	Exoribonuclease, phosphorolytic domain 2
Family	IPR033196	Exosome complex component Rrp43
Homologous_superfamily	IPR020568	Ribosomal protein uS5 domain 2-type superfamily
Homologous_superfamily	IPR027408	PNPase/RNase PH domain superfamily
Homologous_superfamily	IPR036345	Exoribonuclease, PH domain 2 superfamily

Domain Details Per Protein

Protein	Length	Exoribonuclease, PH domain 2 superfamily	Exoribonuclease, phosphorolytic domain 1	Exoribonuclease, phosphorolytic domain 2	Exosome complex component Rrp43	PNPase/RNase PH domain superfamily	Ribosomal protein uS5 domain 2-type superfamily
UniProtKB:Q6DRN4 InterPro	277

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	exosc8-201 (1) Ensembl	Havana	969 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	exosc8-002 (1) Ensembl	Havana	847 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	exosc8-003 (1) Ensembl	Havana	407 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations