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General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-1731
Gene Name: leucine-rich, glioma inactivated 1a
Gene Symbol: lgi1a    Nomenclature History

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Previous Names: fb78h12, wu:fb78h12, zgc:65886

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have catalytic activity. Involved in brain development; locomotory behavior; and myelination. Human ortholog(s) of this gene implicated in familial temporal lobe epilepsy 1. Is expressed in digestive system; heart; immature eye; nervous system; and skeletal muscle. Orthologous to human LGI1 (leucine rich glioma inactivated 1).
Genome Resources: Alliance (1),  Gene:323011 (1),  Ensembl(GRCz11):ENSDARG00000020493 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2008 [cssl:d0363]
  1 figure (1 image) from Thisse et al., 2008 [cssl:d0758]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18184 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lgi1a N/A 1
    MO2-lgi1a N/A 2
    DISEASE ASSOCIATED WITH lgi1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial temporal lobe epilepsy 1 Alliance Epilepsy, familial temporal lobe, 1 600512
    DISEASE ASSOCIATED WITH lgi1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myelination (more)
    Cellular Component cellular_component (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 5)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lgi1a No data available
    MARKER RELATIONSHIPS
    lgi1a Contained in: [BAC] DKEY-38O8 (1) (order this)
    lgi1a Encodes: [EST] cssl:d0363 (1) (order this), cssl:d0758 (1) (order this), fb78h12
    [cDNA] MGC:65886 (1) (order this), MGC:77431 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199627 (1) 2556 bp
    Genomic GenBank:CU570800 (1) 60094 bp
    Select Tool
    Polypeptide UniProtKB:Q2HPG2 (1) 537 aa
    Sequence Clusters UniGene:1612 (1)
    Sequence Information (all 27)
    ORTHOLOGY for lgi1a ( Chr: 13 )
    CITATIONS (23)