Gene

clcn3

ID

ZDB-GENE-030131-1699

Name

chloride channel 3

Symbol

clcn3 Nomenclature History

Previous Names

fb78c02
wu:fb78c02

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have chloride ion binding activity; solute:proton antiporter activity; and voltage-gated chloride channel activity. Predicted to be involved in chloride transport and transmembrane transport. Predicted to localize to Golgi apparatus; cytoplasmic vesicle; and integral component of plasma membrane. Is expressed in several structures, including eye; female organism; heart; liver; and pleuroperitoneal region. Orthologous to human CLCN3 (chloride voltage-gated channel 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With clcn3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with hypotonia and brain abnormalities	619512
		Neurodevelopmental disorder with seizures and brain abnormalities	619517

Associated With clcn3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000644	CBS domain
Family	IPR001807	Chloride channel, voltage gated
Family	IPR002245	Chloride channel ClC-3
Homologous_superfamily	IPR014743	Chloride channel, core
Homologous_superfamily	IPR046342	CBS domain superfamily

Domain Details Per Protein

Protein	Length	CBS domain	CBS domain superfamily	Chloride channel ClC-3	Chloride channel, core	Chloride channel, voltage gated
UniProtKB:A0A8M9Q891 InterPro	799
UniProtKB:A0A8M9Q239 InterPro	824
UniProtKB:A0A8M9PPD0 InterPro	824
UniProtKB:A0A8M9QHF3 InterPro	849
UniProtKB:A0A8M9Q887 InterPro	874

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	clcn3-202 (1) Ensembl	Havana	5596 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	clcn3-204 (1) Ensembl	Havana	518 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	clcn3-205 (1) Ensembl	Havana	2277 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	clcn3-004 (1) Ensembl	Havana	638 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations