ZFIN ID: ZDB-GENE-030131-1662
Gene Name: desmoplakin b
Gene Symbol: dspb    Nomenclature History

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Previous Names: fi04e12, wu:fb77d08, wu:fi04e12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have cell adhesion molecule binding activity. Predicted to be involved in cell-cell adhesion. Predicted to localize to cell junction and cytoskeleton. Is expressed in several structures, including epidermis; head; heart; otic vesicle; and solid lens vesicle. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; and dilated cardiomyopathy. Orthologous to human DSP (desmoplakin).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000076673 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa37181 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37182 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39311 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43549 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43550 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dspb N/A 1
    DISEASE ASSOCIATED WITH dspb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    arrhythmogenic right ventricular dysplasia 8 Alliance Arrhythmogenic right ventricular dysplasia 8 607450
    Carvajal syndrome Alliance Cardiomyopathy, dilated, with woolly hair and keratoderma 605676
    Dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis 615821
    Epidermolysis bullosa, lethal acantholytic 609638
    Keratosis palmoplantaris striata II 612908
    Skin fragility-woolly hair syndrome 607655
    DISEASE ASSOCIATED WITH dspb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-cell adhesion (more)
    Cellular Component cytoplasm (more)
    Molecular Function structural molecule activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dspb No data available
    MARKER RELATIONSHIPS
    dspb Encodes: [EST] fb77d08, fi04e12
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA GenBank:AW115880 (1) 631 nt
    Sequence Information (all 4)
    ORTHOLOGY for dspb ( Chr: 20 )
    CITATIONS (11)