Gene

fmnl3

ID
ZDB-GENE-030131-1571
Name
formin-like 3
Symbol
fmnl3 Nomenclature History
Previous Names
  • fb74h11
  • si:ch73-60e21.1
  • wu:fb74h11
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Is predicted to enable actin filament binding activity. Involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Acts upstream of or within actin filament polymerization; filopodium assembly; and sprouting angiogenesis. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; myotome; nervous system; and trunk. Orthologous to human FMNL3 (formin like 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fmnl3 Human Ortholog
No data available
Associated With fmnl3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR010472 Formin, FH3 domain
Domain IPR010473 Formin, GTPase-binding domain
Domain IPR014767 Diaphanous autoregulatory (DAD) domain
Domain IPR014768 Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Domain IPR015425 Formin, FH2 domain
Family IPR027655 Formin-like protein 3
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR042201 Formin, FH2 domain superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold Diaphanous autoregulatory (DAD) domain Formin, FH2 domain Formin, FH2 domain superfamily Formin, FH3 domain Formin, GTPase-binding domain Formin-like protein 3 Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
UniProtKB:E9QG32 468
UniProtKB:Q6NXC0 1047
UniProtKB:F1R067 485
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations