ZFIN ID: ZDB-GENE-030131-1500
Gene Name: N-acetylneuraminic acid synthase a
Gene Symbol: nansa    Nomenclature History

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Previous Names: nans, fb73c01, wu:fb73c01, zgc:77126 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have N-acylneuraminate-9-phosphate synthase activity. Involved in embryonic skeletal system development. Is expressed in several structures, including alar plate midbrain region; axis; digestive system; hatching gland; and polster. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Genevieve-type. Orthologous to human NANS (N-acetylneuraminate synthase).
Genome Resources: Alliance (1),  Gene:322780 (1),  Ensembl(GRCz11):ENSDARG00000045620 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2004 [IMAGE:6909117]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa39567 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nansa N/A 1
    DISEASE ASSOCIATED WITH nansa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spondyloepimetaphyseal dysplasia, Genevieve-type Alliance Spondyloepimetaphyseal dysplasia, Camera-Genevieve type 610442
    DISEASE ASSOCIATED WITH nansa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic skeletal system development (more)
    Cellular Component cellular_component (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nansa-201 (1)    Ensembl 1383
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nansa No data available
    MARKER RELATIONSHIPS
    nansa Contained in: [BAC] CH73-340C23 (1), CH211-109N19 (1)
    nansa Encodes: [EST] fb73c01, IMAGE:6909117 (1)
    [cDNA] MGC:77126 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_206829 (1) 1350 nt
    Genomic GenBank:CT033816 (1) 166556 nt
    Select Tool
    Polypeptide UniProtKB:F1R1P6 (1) 359 aa
    Sequence Information (all 14)
    ORTHOLOGY for nansa ( Chr: 1 )
    CITATIONS (23)