ZFIN ID: ZDB-GENE-030131-1452
Gene Name: arachidonate 12-lipoxygenase
Gene Symbol: alox12    Nomenclature History

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Previous Names: ALOX1 (1), LOX1 (1), wu:fb72a11, zgc:64120

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits arachidonate 12(S)-lipoxygenase activity and calcium ion binding activity. Involved in oxidation-reduction process. Localizes to nucleus. Is expressed in several structures, including EVL; digestive system; epidermal cell; epidermis; and periderm. Orthologous to several human genes including ALOX12 (arachidonate 12-lipoxygenase, 12S type).
Genome Resources: Alliance (1),  Gene:322732 (1),  Ensembl(GRCz11):ENSDARG00000069463 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-alox12 N/A 1
MO2-alox12 N/A 1
DISEASE ASSOCIATED WITH alox12 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH alox12 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component nucleus (more)
Molecular Function arachidonate 12(S)-lipoxygenase activity (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA alox12-201 (1)    Ensembl 3595
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM alox12 No data available
MARKER RELATIONSHIPS
alox12 Contained in: [BAC] DKEY-6N21 (1) (order this)
alox12 Encodes: [EST] fb72a11, IMAGE:7138147 (1)
[cDNA] MGC:64120 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_199618 (1) 3567 nt
Genomic GenBank:BX005022 (1) 217582 nt Blast at MegaBLAST
Polypeptide UniProtKB:Q7T2A9 (1) 670 aa
Sequence Information (all 11)
ORTHOLOGY for alox12 ( Chr: 7 )
CITATIONS (28)