ZFIN ID: ZDB-GENE-030131-1346
Gene Name: hydroxysteroid (17-beta) dehydrogenase 12b
Gene Symbol: hsd17b12b    Nomenclature History

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Previous Names: fb68b12, wu:fb68b12, zf 3.3 (1), zgc:73289

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have estradiol 17-beta-dehydrogenase activity. Predicted to be involved in estrogen biosynthetic process; fatty acid biosynthetic process; and oxidation-reduction process. Predicted to localize to endoplasmic reticulum; endoplasmic reticulum membrane; and integral component of membrane. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).
Genome Resources: Alliance (1),  Gene:322626 (1),  Ensembl(GRCz11):ENSDARG00000035872 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:73289]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7138477]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14493 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31592 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hsd17b12b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hsd17b12b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process estrogen biosynthetic process (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function estradiol 17-beta-dehydrogenase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hsd17b12b-201 (1)    Ensembl 2297
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hsd17b12b No data available
    MARKER RELATIONSHIPS
    hsd17b12b Encodes: [EST] fb68b12, IMAGE:7138477 (1), wz11236 (1)
    [cDNA] MGC:73289 (1), MGC:173985 (1), MGC:174492 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199613 (1) 2282 nt
    Genomic GenBank:CU695004 (1) 31220 nt
    Select Tool
    Polypeptide UniProtKB:A7MCK2 (1) 311 aa
    Sequence Information (all 25)
    ORTHOLOGY for hsd17b12b ( Chr: 7 )
    CITATIONS (26)