Gene

tat

ID
ZDB-GENE-030131-1144
Name
tyrosine aminotransferase
Symbol
tat Nomenclature History
Previous Names
  • si:ch211-238a12.1
  • wu:fb60g09
  • zgc:154059
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have L-tyrosine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-phenylalanine catabolic process; biosynthetic process; and tyrosine catabolic process. Is expressed in liver. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Orthologous to human TAT (tyrosine aminotransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Cort├ęs et al., 2017
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tat Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
tyrosinemia type II Alliance Tyrosinemia, type II 276600
Associated With tat Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site
Domain IPR004839 Aminotransferase, class I/classII
Family IPR005957 Tyrosine aminotransferase
Family IPR005958 Tyrosine/nicotianamine aminotransferase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015422 Pyridoxal phosphate-dependent transferase domain 1
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Aminotransferase, class I/classII Aminotransferases, class-I, pyridoxal-phosphate-binding site Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase domain 1 Pyridoxal phosphate-dependent transferase, major domain Tyrosine aminotransferase Tyrosine/nicotianamine aminotransferase
UniProtKB:F1Q759 444
UniProtKB:A0JMN6 444
UniProtKB:Q1L991 451
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations