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ZIRC
ZFIN ID: ZDB-GENE-030131-1060
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Gene Name: cytochrome P450, family 27, subfamily A, polypeptide 1, gene 4
Gene Symbol: cyp27a1.4    Nomenclature History

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Previous Names: si:dkeyp-68f9.12, wu:fb58e08 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Human ortholog(s) of this gene implicated in cerebrotendinous xanthomatosis. Is expressed in liver. Orthologous to human CYP27A1 (cytochrome P450 family 27 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:322341 (1),  Ensembl(GRCz11):ENSDARG00000055159 (2)
GENE EXPRESSION
All Expression Data: Fig. S2 from Peng et al., 2017
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21547 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa34706 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp27a1.4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp27a1.4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Molecular Function heme binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001128 (1)
  • InterPro:IPR002401 (1)
  • InterPro:IPR017972 (1)
  • InterPro:IPR036396 (1)
  • PROSITE:PS00086 (1)
  • Pfam:PF00067 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp27a1.4-201 (1)    Ensembl 1819
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp27a1.4 No data available
    MARKER RELATIONSHIPS
    cyp27a1.4 Contained in: [BAC] DKEYP-68F9 (1)
    cyp27a1.4 Encodes: [EST] fb58e08
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001328513 (1)
    Select Tool
    Genomic GenBank:BX001051 (1) 213486 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q502F8 (1) 528 aa
    Select Tool
    Sequence Clusters UniGene:40298 (1)
    Sequence Information (all 16)
    ORTHOLOGY for cyp27a1.4 ( Chr: 9 )
    CITATIONS (17)