ZFIN Gene: smc2

ZFIN ID: ZDB-GENE-030131-105

ZFIN ID: ZDB-GENE-030131-105

Gene Name:

structural maintenance of chromosomes 2

Gene Symbol:

smc2

Sequence Ontology ID :

SO:0000704

Previous Names:

fb92e05, hm:zeh1628, wu:fb92e05 (1), zeh1628, zgc:55326 (1)

Location:

Chr: 1 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have ATP binding activity. Predicted to be involved in chromosome organization. Predicted to localize to the chromosome and nucleus. Orthologous to human SMC2 (structural maintenance of ...

GENE EXPRESSION
All Expression Data:	14 figures from 2 publications
Directly Submitted Expression Data:	6 figures (9 images) from Thisse et al., 2004 [MGC:55326]
	6 figures (15 images) from Thisse et al., 2004 [IMAGE:7165175]
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
	artery central nervous system ciliary marginal zone forebrain ventricle ventricular zone fourth ventricle gut hindbrain proliferative region midbrain hindbrain boundary optic cup optic tectum optic vesicle otic vesicle pectoral fin pectoral fin musculature pharyngeal arch 3-7 pharyngeal arch 3-7 skeleton proliferative region retina unspecified vein ventricular zone
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa11094	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa11231	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa13643	Point Mutation	Unknown	Missense, Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
zko372a	Small Deletion	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)

Targeting reagents:

CRISPR1-smc2 (1)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH smc2 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH smc2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	chromosome organization (more)
Cellular Component	chromosome (more)
Molecular Function	ATP binding (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR003395 (1) InterPro:IPR010935 (1) InterPro:IPR024704 (1) InterPro:IPR027120 (1) InterPro:IPR027417 (1) InterPro:IPR036277 (1)	Pfam:PF02463 (1) Pfam:PF06470 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	smc2-002 (1)	441	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	smc2-201 (1)	4073	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM smc2 No data available

MARKER RELATIONSHIPS

smc2Contained in:	[BAC] DKEY-245P14 (1) (order this)
smc2Contains:	[SNP] rs3727514 (1), rs3727515 (1), rs3727516 (1), rs3727517 (1), rs3727518 (1), rs3727519 (1), rs3727520 (1), rs3727521 (1), rs3727522 (1), rs3727523 (1), rs3727524 (1), rs3727525 (1), rs3727526 (1), rs3727527 (1)
smc2Encodes:	[EST] fb92e05, IMAGE:7165175 (1) (order this), zeh1628 [cDNA] MGC:55326 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_199542 (1)	4073bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX548248 (1)	195620bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B8A5K9 (1)	1199aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:24234 (1)

Sequence Information (all 15)

OTHER smc2 GENE PAGES

Alliance (1)

Gene:321452 (1)

VEGA:OTTDARG00000019512 (1)

Ensembl(GRCz11):ENSDARG00000017744 (1)

ORTHOLOGY for smc2 (Chr: 1)

CITATIONS (23)

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