ZFIN ID: ZDB-GENE-030131-1033
Gene Name: agrin
Gene Symbol: agrn    Nomenclature History

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Previous Names: agrin, hm:gc12, sb:eu553, wu:fb57e07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase inhibitor activity. Involved in anterior/posterior pattern specification and nervous system development. Predicted to localize to integral component of membrane. Is expressed in several structures, including immature eye; nervous system; neural tube; notochord; and pronephric duct. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin).
Genome Resources: Alliance (1),  Gene:565373 (1),  Ensembl(GRCz11):ENSDARG00000079388 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022570Tg Transgenic Insertion Unknown Unknown DNA
la022571Tg Transgenic Insertion Unknown Unknown DNA
p168 Indel Donor Splice Site of Exon 31 Unknown CRISPR
sa381 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11435 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12413 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15437 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25196 Point Mutation Unknown Premature Stop ENU
    sa29921 Point Mutation Unknown Premature Stop ENU
    sa43979 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43980 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45798 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-agrn 1
    MO1-agrn N/A 2
    MO2-agrn N/A 6
    DISEASE ASSOCIATED WITH agrn HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital myasthenic syndrome 8 Alliance Myasthenic syndrome, congenital, 8, with pre- and postsynaptic defects 615120
    DISEASE ASSOCIATED WITH agrn VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA agrn-202 (1)    Ensembl 8434
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM agrn No data available
    MARKER RELATIONSHIPS
    agrn Contained in: [BAC] CH73-233L1 (1), CH73-313G1 (1), CH211-135H16 (1), CH211-203J19 (1), DKEY-69N13 (1) (order this), DKEYP-73G7 (1)
    [Fosmid] CH1073-121E5 (1)
    agrn Contains: [SNP] rs3729254 (1), rs3729255 (1), rs3729256 (1)
    agrn Encodes: [EST] eu553 (1), fb57e07
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001177452 (1) 6245 nt
    Genomic RefSeq:NW_018395149 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:B3GQ72 (1) 2028 aa
    Sequence Information (all 62)
    ORTHOLOGY for agrn ( Chr: 23 )
    CITATIONS (43)