ZFIN ID: ZDB-GENE-030131-1028
Gene Name: sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
Gene Symbol: sirt2    Nomenclature History

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Previous Names: wu:fb57d05, zgc:77003

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have NAD+ binding activity; protein deacetylase activity; and transcription factor binding activity. Involved in cilium assembly and negative regulation of angiogenesis. Predicted to localize to several cellular components, including Schmidt-Lanterman incisure; main axon; and microtubule cytoskeleton. Is expressed in liver and retina. Orthologous to human SIRT2 (sirtuin 2).
Genome Resources: Alliance (1),  Gene:322309 (1),  Ensembl(GRCz11):ENSDARG00000011488 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55966]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019489Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9082 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13413 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sirt2 N/A 1
    MO2-sirt2 N/A 2
    MO3-sirt2 N/A 1
    MO4-sirt2 N/A 1
    MO5-sirt2 N/A 1
    DISEASE ASSOCIATED WITH sirt2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sirt2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component centriole (more)
    Molecular Function NAD-dependent histone deacetylase activity (H4-K16 specific) (more)
    GO Terms (all 45)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sirt2-201 (1)    Ensembl 2589
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sirt2 No data available
    MARKER RELATIONSHIPS
    sirt2 Contained in: [Fosmid] CH1073-228B5 (1)
    sirt2 Encodes: [EST] fb57d05
    [cDNA] MGC:55966 (1), MGC:77003 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199596 (1) 2545 nt
    Genomic GenBank:CU693501 (1) 37734 nt
    Select Tool
    Polypeptide UniProtKB:F1QE37 (1) 379 aa
    Sequence Information (all 22)
    ORTHOLOGY for sirt2 ( Chr: 15 )
    CITATIONS (36)