Gene

smad7

ID

ZDB-GENE-030128-3

Name

SMAD family member 7

Symbol

smad7 Nomenclature History

Previous Names

madh7
fj60c10
wu:fj60c10

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable I-SMAD binding activity and transcription regulator inhibitor activity. Predicted to be involved in several processes, including SMAD protein signal transduction; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including axis; ectoderm; immature eye; midbrain neural tube; and nervous system. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77461 (1 image)
eu607 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smad7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Colorectal cancer, susceptibility to, 3}	612229

Associated With smad7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001132	SMAD domain, Dwarfin-type
Domain	IPR003619	MAD homology 1, Dwarfin-type
Domain	IPR013019	MAD homology, MH1
Family	IPR013790	Dwarfin
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR017855	SMAD-like domain superfamily
Homologous_superfamily	IPR036578	SMAD MH1 domain superfamily