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ZIRC
ZFIN ID: ZDB-GENE-030127-1
Gene Name: NK3 homeobox 2
Gene Symbol: nkx3-2    Nomenclature History

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Previous Names: nkx3.2 (1), bapx1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in embryonic viscerocranium morphogenesis. Predicted to localize to the nucleus. Is expressed in several structures, including neuromast; notochord; pharyngeal arch; pharyngeal endoderm; and skeletal system. Orthologous to human NKX3-2 (NK3 homeobox 2).
Genome Resources: Alliance (1), Gene:337865 (1), Ensembl(GRCz11):ENSDARG00000037639 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-nkx3-2 N/A 3
MO2-nkx3-2 N/A 1
DISEASE ASSOCIATED WITH nkx3-2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Spondylo-megaepiphyseal-metaphyseal dysplasia 613330
DISEASE ASSOCIATED WITH nkx3-2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process embryonic viscerocranium morphogenesis (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 9)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nkx3.2-201 (1)    Ensembl 1492
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIESNo data available
PLASMIDSNo data available
CONSTRUCTS WITH SEQUENCES FROM nkx3-2No data available
MARKER RELATIONSHIPS
nkx3-2Contained in: [BAC] CH73-377P23 (1) (order this)
[Fosmid] CH1073-380M10 (1) (order this)
nkx3-2Encodes: [EST] eu470 (1)
[cDNA] MGC:175077 (1) (order this), MGC:193888 (1), MGC:193902 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_178132 (1) 1357bp
Genomic GenBank:FP243378 (1) 44719bp
Select Tool
Polypeptide UniProtKB:B0JZM4 (1) 245aa
Sequence Clusters UniGene:21063 (1)
Sequence Information (all 25)
ORTHOLOGY for nkx3-2 (Chr: 14)
CITATIONS (52)