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Gene

nkx3-2

ID
ZDB-GENE-030127-1
Name
NK3 homeobox 2
Symbol
nkx3-2 Nomenclature History
Previous Names
  • nkx3.2 (1)
  • bapx1 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic viscerocranium morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including neuromast; notochord; pharyngeal arch; pharyngeal endoderm; and skeletal system. Orthologous to human NKX3-2 (NK3 homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
37 figures from 25 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nkx3-2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Spondylo-megaepiphyseal-metaphyseal dysplasia 613330
Associated With nkx3-2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR020479 Homeobox domain, metazoa
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox domain, metazoa Homeobox-like domain superfamily
UniProtKB:B0JZM4 245
UniProtKB:Q803Z6 245
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations