ZFIN ID: ZDB-GENE-021223-2
Gene Name: melanocortin 4 receptor
Gene Symbol: mc4r
Sequence Ontology ID : SO:0000704

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Previous Names: zMC4, si:dkey-151m6.62

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(Including Attributions)
Location: Chr: 2 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 11 figures from 7 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
  brain, dorsal periventricular hypothalamus, forebrain, habenula (all 12) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa122 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa148 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa149 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: CRISPR1-mc4r (1), MO1-mc4r (1), MO2-mc4r (1)
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in: feeding behavior, whole organism
    DISEASE ASSOCIATED WITH mc4r HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    obesity Obesity, autosomal dominant 601665
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenylate cyclase-activating G-protein coupled receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function melanocortin receptor activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000155 (1)
  • InterPro:IPR000276 (1)
  • InterPro:IPR001671 (1)
  • InterPro:IPR001908 (1)
  • InterPro:IPR017452 (1)
  • PROSITE:PS00237 (1)
  • PROSITE:PS50262 (1)
  • Pfam:PF00001 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA mc4r-001 (1) 1084
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM mc4r No data available
    MARKER RELATIONSHIPS
    mc4rContained in: [BAC] DKEY-151M6 (1) (order this)
    mc4rEncodes: [cDNA] MGC:194184 (1) (order this), MGC:194203 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_173278 (1) 981bp
    Genomic GenBank:CR925777 (1) 210659bp Blast at MegaBLAST
    Polypeptide UniProtKB:B0V1P1 (1) 326aa
    Sequence Clusters UniGene:45846 (1)
    Sequence Information (all 18)
    OTHER mc4r GENE PAGES
  • Alliance (1)
  • Gene:286833 (1)
  • VEGA:OTTDARG00000023869 (1)
  • Ensembl(GRCz10):ENSDARG00000015515 (1)
  • ORTHOLOGY for mc4r (Chr: 2)
    CITATIONS (43)