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General Information
ZIRC
ZFIN ID: ZDB-GENE-021206-12
Gene Name: HNF1 homeobox a
Gene Symbol: hnf1a
Sequence Ontology ID : SO:0001217

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Previous Names: hnf1-a (1), tcf1 (1), af244934-22s, xx:af244934-22s

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(Including Attributions)
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Involved in type B pancreatic cell development. Predicted to localize to the  ...
GENE EXPRESSION
All Expression Data: 5 figures from 5 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu405]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents:
DISEASE ASSOCIATED WITH hnf1a HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
familial hepatic adenoma Hepatic adenoma, somatic 142330
maturity-onset diabetes of the young type 3 MODY, type III 600496
nonpapillary renal cell carcinoma Renal cell carcinoma 144700
type 1 diabetes mellitus {Diabetes mellitus, insulin-dependent} 222100
type 1 diabetes mellitus 20 Diabetes mellitus, insulin-dependent, 20 612520
type 2 diabetes mellitus {Diabetes mellitus, noninsulin-dependent, 2} 125853
DISEASE ASSOCIATED WITH hnf1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process endocrine pancreas development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 11)
TRANSCRIPTS
Type Name Length (bp) Analysis
mRNA hnf1a-201 (1) 2961
aberrant processed transcript hnf1a-202 (1) 1567
GENE PRODUCT DESCRIPTION
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS
Addgene
CONSTRUCTS WITH SEQUENCES FROM hnf1a No data available
MARKER RELATIONSHIPS
hnf1a Contained in: [BAC] CH211-170D8 (1) (order this), DKEY-117K10 (1) (order this)
hnf1a Encodes: [EST] af244934, eu405 (1)
[cDNA] MGC:194574 (1) (order this), MGC:194584 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_170764 (1) 2979 bp
Genomic GenBank:CR376731 (1) 130762 bp
Select Tool
Polypeptide UniProtKB:F2Z4S1 (1) 560 aa
Sequence Clusters UniGene:85278 (1)
Sequence Information (all 27)
ORTHOLOGY for hnf1a ( Chr: 8 )
CITATIONS (31)