Gene

drd2a

ID
ZDB-GENE-021119-2
Name
dopamine receptor D2a
Symbol
drd2a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have adrenergic receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; behavioral response to cocaine; and regulation of ion transport. Predicted to localize to integral component of plasma membrane and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); end stage renal failure; mental depression; obesity; and type 2 diabetes mellitus. Is expressed in nervous system. Orthologous to human DRD2 (dopamine receptor D2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Liu et al., 2006
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With drd2a Human Ortholog
No data available
Associated With drd2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000929 Dopamine receptor family
Family IPR001922 Dopamine D2 receptor
Domain Details Per Protein
Protein Length Dopamine D2 receptor Dopamine receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:Q8AWE0 448
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations