Gene

drd3

ID
ZDB-GENE-021119-1
Name
dopamine receptor D3
Symbol
drd3 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of cytosolic calcium ion concentration; and regulation of ion transport. Predicted to localize to integral component of plasma membrane. Is expressed in myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (dopamine receptor D3).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 8 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With drd3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
essential tremor 1 Alliance {Essential tremor, hereditary, 1} 190300
schizophrenia Alliance {Schizophrenia, susceptibility to} 181500
Associated With drd3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000929 Dopamine receptor family
Domain Details Per Protein
Protein Length Dopamine receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:Q8AWE1 454
UniProtKB:A0A2R8Q6N5 454
UniProtKB:F1QG18 472
UniProtKB:Q6DGJ2 452
UniProtKB:F1R1L1 466
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations