ZFIN ID: ZDB-GENE-021022-3
Gene Name: K(lysine) acetyltransferase 6A
Gene Symbol: kat6a    Nomenclature History

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Previous Names: bmd (1), monocytic leukemia zinc finger, moz (1), myst3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits histone acetyltransferase activity. Involved in several processes, including embryonic body morphogenesis; neural crest cell fate specification; and skeletal system morphogenesis. Localizes to nuclear chromatin. Is expressed in head. Human ortholog(s) of this gene implicated in acute myeloid leukemia and autosomal dominant non-syndromic intellectual disability 32. Orthologous to human KAT6A (lysine acetyltransferase 6A).
Genome Resources: Alliance (1),  Gene:266966 (1),  Ensembl(GRCz11):ENSDARG00000018907 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b719 Small Deletion Exon 14 Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • b999 Point Mutation Exon 16 Premature Stop ENU
    sa2235 Point Mutation Unknown Premature Stop ENU
    sa6053 Point Mutation Unknown Premature Stop ENU
    sa18269 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45190 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45191 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kat6a N/A 1
    MO2-kat6a N/A 1
    MO3-kat6a N/A 3
    MO4-kat6a N/A 1
    DISEASE ASSOCIATED WITH kat6a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Arboleda-Tham syndrome Alliance Arboleda-Tham syndrome 616268
    DISEASE ASSOCIATED WITH kat6a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification (more)
    Cellular Component nuclear chromatin (more)
    Molecular Function histone acetyltransferase activity (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kat6a-201 (1)    Ensembl 7796
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kat6a No data available
    MARKER RELATIONSHIPS
    kat6a Contained in: [BAC] CH211-185J11 (1), CH211-244O22 (1)
    kat6a Contains: [BAC END] zc4o19.ya, zc114e16.za
    kat6a Encodes: [cDNA] MGC:194595 (1), MGC:194602 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001123312 (1) 9059 nt
    Genomic GenBank:CR392037 (1) 140415 nt
    Select Tool
    Polypeptide UniProtKB:B3DK07 (1) 2247 aa
    Sequence Information (all 20)
    ORTHOLOGY for kat6a ( Chr: 5 )
    CITATIONS (36)