Gene
guk1b
- ID
- ZDB-GENE-020916-1
- Name
- guanylate kinase 1b
- Symbol
- guk1b Nomenclature History
- Previous Names
-
- guk1
- zgc:73128
- zgc:73217
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable GMP kinase activity. Predicted to act upstream of or within phosphorylation and purine nucleotide metabolic process. Predicted to be located in cytoplasm; membrane; and photoreceptor inner segment. Predicted to be active in cytosol. Is expressed in epiphysis; retina; retinal outer nuclear layer; and retinal photoreceptor layer. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome-21. Orthologous to human GUK1 (guanylate kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73128 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome-21 | Alliance | Mitochondrial DNA depletion syndrome 21 | 621071 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Family | IPR017665 | Guanylate kinase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Guanylate kinase | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6PC32 | InterPro | 223 | |||||
| UniProtKB:B8JJJ6 | InterPro | 197 | |||||
| UniProtKB:A0AB32U008 | InterPro | 223 |
Interactions and Pathways
No data available
Plasmids
No data available