Gene

caspb

ID
ZDB-GENE-020812-1
Name
caspase b
Symbol
caspb Nomenclature History
Previous Names
  • caspy2
  • casp19a (1)
  • zgc:109807
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Enables cysteine-type endopeptidase activator activity; lipopolysaccharide binding activity; and peptidase activity. Involved in defense response to bacterium; positive regulation of pyroptosis; and self proteolysis. Acts upstream of or within positive regulation of apoptotic process and pyroptosis. Part of inflammasome complex. Is expressed in several structures, including digestive system; heart; immune system; integument; and muscle. Orthologous to human CASP4 (caspase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With caspb Human Ortholog
No data available
Associated With caspb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016129 Peptidase family C14A, His active site
Active_site IPR033139 Peptidase family C14A, cysteine active site
Domain IPR001309 Peptidase C14, p20 domain
Domain IPR002138 Peptidase C14, caspase non-catalytic subunit p10
Domain IPR004020 DAPIN domain
Domain IPR015917 Peptidase C14A, caspase catalytic domain
Family IPR002398 Peptidase C14 family
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR029030 Caspase-like domain superfamily
Domain Details Per Protein
Protein Length Caspase-like domain superfamily DAPIN domain Death-like domain superfamily Peptidase C14A, caspase catalytic domain Peptidase C14, caspase non-catalytic subunit p10 Peptidase C14 family Peptidase C14, p20 domain Peptidase family C14A, cysteine active site Peptidase family C14A, His active site
UniProtKB:Q504J1 404
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Removed orthology to human CASP1 curated from Woods et al. 2005. Not clear if CASP1 or CASP5 is ortholog.
Citations