ZFIN ID: ZDB-GENE-020809-1
Gene Name: roundabout, axon guidance receptor, homolog 4 (Drosophila)
Gene Symbol: robo4    Nomenclature History

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Previous Names: sc:d0823, wu:fa16f09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have cell-cell adhesion mediator activity. Involved in several processes, including plasma membrane bounded cell projection assembly; positive regulation of Rac protein signal transduction; and positive regulation of cell-matrix adhesion. Localizes to intrinsic component of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; neural tube; optic cup; and vestibuloauditory system. Human ortholog(s) of this gene implicated in bicuspid aortic valve disease. Orthologous to human ROBO4 (roundabout guidance receptor 4).
Genome Resources: Alliance (1),  Gene:560765 (1),  Ensembl(GRCz11):ENSDARG00000009387 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
jh176 Small Deletion Unknown Unknown CRISPR
sa6175 Point Mutation Unknown Premature Stop ENU
sa8702 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21760 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24878 Point Mutation Unknown Premature Stop ENU
    sa38805 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-robo4 1
    MO1-robo4 N/A 3
    MO2-robo4 N/A 2
    MO3-robo4 N/A 1
    DISEASE ASSOCIATED WITH robo4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Aortic valve disease 8 618496
    DISEASE ASSOCIATED WITH robo4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endothelial cell migration (more)
    Cellular Component intrinsic component of plasma membrane (more)
    Molecular Function cell-cell adhesion mediator activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA robo4-201 (1)    Ensembl 3715
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM robo4 No data available
    MARKER RELATIONSHIPS
    robo4 Contained in: [BAC] CH211-164N21 (1), DKEY-30J19 (1) (order this)
    robo4 Contains: [SNP] rs3728312 (1), rs3728313 (1)
    robo4 Encodes: [EST] fa16f09 (1)
    [cDNA] cssl:d823 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005172710 (1)
    Genomic GenBank:AL845320 (1) 183417 nt
    Select Tool
    Polypeptide UniProtKB:F1RE66 (1) 1134 aa
    Sequence Information (all 24)
    ORTHOLOGY for robo4 ( Chr: 10 )
    CITATIONS (38)