Gene

robo4

ID
ZDB-GENE-020809-1
Name
roundabout, axon guidance receptor, homolog 4 (Drosophila)
Symbol
robo4 Nomenclature History
Previous Names
  • sc:d0823
  • wu:fa16f09
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have cell-cell adhesion mediator activity. Involved in several processes, including plasma membrane bounded cell projection assembly; positive regulation of Rac protein signal transduction; and positive regulation of cell-matrix adhesion. Localizes to intrinsic component of plasma membrane. Human ortholog(s) of this gene implicated in bicuspid aortic valve disease. Is expressed in several structures, including cardiovascular system; central nervous system; neural tube; optic cup; and vestibuloauditory system. Orthologous to human ROBO4 (roundabout guidance receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With robo4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
aortic valve disease 3 Alliance Aortic valve disease 3 618496
Associated With robo4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Family IPR043204 Basigin-like
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Basigin-like Fibronectin type III Fibronectin type III superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2
UniProtKB:A4JYG5 591
UniProtKB:Q71B05 1134
UniProtKB:A0A2R8QSG8 140
UniProtKB:A0A2R8QSX8 1025
UniProtKB:F1RE66 1134
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations