Gene

esr1

ID

ZDB-GENE-020806-5

Name

estrogen receptor 1

Symbol

esr1 Nomenclature History

Previous Names

ER[a] (1)
ERalpha (1)
NR3A1 (1)
zfER[a] (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Exhibits estrogen receptor activity; nuclear receptor activity; and steroid hormone binding activity. Involved in several processes, including cellular response to estrogen stimulus; posterior lateral line neuromast primordium migration; and response to estradiol. Predicted to localize to nucleus. Is expressed in several structures, including diencephalon; head; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); systemic scleroderma; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

48 figures from 31 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu209 (1 image)
af349412 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With esr1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
breast cancer	Alliance	Breast cancer, somatic	114480
migraine	Alliance	{Migraine, susceptibility to}	157300
		Estrogen resistance	615363
		{Myocardial infarction, susceptibility to}	608446

Associated With esr1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Domain	IPR001628	Zinc finger, nuclear hormone receptor-type
Family	IPR001292	Estrogen receptor
Family	IPR001723	Nuclear hormone receptor
Family	IPR024178	Estrogen receptor/oestrogen-related receptor
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily

Domain Details Per Protein

Protein	Length	Estrogen receptor	Estrogen receptor/oestrogen-related receptor	Nuclear hormone receptor	Nuclear hormone receptor, ligand-binding domain	Nuclear hormone receptor-like domain superfamily	Zinc finger, NHR/GATA-type	Zinc finger, nuclear hormone receptor-type
UniProtKB:Q9I984 InterPro	276
UniProtKB:U3Q5I8 InterPro	79
UniProtKB:E5G0W5 InterPro	21
UniProtKB:A0A0R4ID06 InterPro	18
UniProtKB:B4XRZ3 InterPro	621
UniProtKB:P57717 InterPro	569
UniProtKB:F1QL15 InterPro	505
UniProtKB:B4XRZ4 InterPro	505
UniProtKB:J9XWH0 InterPro	18
UniProtKB:B3DGP1 InterPro	569
UniProtKB:E5G0W6 InterPro	93
UniProtKB:A5PMH3 InterPro	569
UniProtKB:A0A2R8QHN3 InterPro	623