ZFIN ID: ZDB-GENE-020806-5
Gene Name: estrogen receptor 1
Gene Symbol: esr1
Sequence Ontology ID : SO:0000704

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Previous Names: ER[a] (1), ERalpha (1), NR3A1 (1), zfER[a] (1)

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
AUTOMATED DESCRIPTION
Exhibits RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding activity and steroid hormone binding activity; involved in several processes, including  ...
GENE EXPRESSION
All Expression Data: 38 figures from 22 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu209]
  7 figures (7 images) from Thisse et al., 2008 [af349412]
Wild-type Stages, Structures: Blastula:512-cell (2.75h-3.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb248 Indel Exon 4 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • sa29373 Point Mutation Unknown Premature Stop ENU
    uab118 Small Deletion Unknown Frameshift, Premature Stop CRISPR
    zf1080 Small Deletion Exon 2 Premature Stop CRISPR
    Targeting reagents:
    PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH esr1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    breast cancer Breast cancer, somatic 114480
    migraine {Migraine, susceptibility to} 157300
    {Atherosclerosis, susceptibility to}
    {HDL response to hormone replacement, augmented}
    {Myocardial infarction, susceptibility to} 608446
    Estrogen resistance 615363
    DISEASE ASSOCIATED WITH esr1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to estrogen stimulus (more)
    Cellular Component nucleus (more)
    Molecular Function estrogen receptor activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000536 (1)
  • InterPro:IPR001292 (1)
  • InterPro:IPR001628 (1)
  • InterPro:IPR001723 (1)
  • InterPro:IPR013088 (1)
  • InterPro:IPR024178 (1)
  • InterPro:IPR035500 (1)
  • PROSITE:PS00031 (1)
  • PROSITE:PS51030 (1)
  • PROSITE:PS51843 (1)
  • Pfam:PF00104 (1)
  • Pfam:PF00105 (1)
  • Pfam:PF02159 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA esr1-202 (1) 3449
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM esr1 No data available
    MARKER RELATIONSHIPS
    esr1Contained in: [BAC] CH73-109I14 (1) (order this), CH73-192G21 (1) (order this), CH211-87A14 (1) (order this), CH211-147O6 (1) (order this)
    esr1Encodes: [EST] af349412 (1) (order this), eu209 (1)
    [cDNA] MGC:193559 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152959 (1) 3439bp
    Genomic GenBank:BX936462 196432bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QHN3 (1) 623aa
    Sequence Clusters UniGene:79999 (1)
    Sequence Information (all 49)
    OTHER esr1 GENE PAGES
  • Alliance (1)
  • Gene:259252 (1)
  • VEGA:OTTDARG00000023543 (1)
  • ORTHOLOGY for esr1 (Chr: 20)
    CITATIONS (247)