ZFIN ID: ZDB-GENE-020806-5
Gene Name: estrogen receptor 1
Gene Symbol: esr1    Nomenclature History

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Previous Names: ER[a] (1), ERalpha (1), NR3A1 (1), zfER[a] (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits estrogen receptor activity; nuclear receptor activity; and steroid hormone binding activity. Involved in several processes, including cellular response to estrogen stimulus; posterior lateral line neuromast primordium migration; and response to estradiol. Predicted to localize to nucleus. Is expressed in several structures, including diencephalon; head; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); systemic scleroderma; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1).
Genome Resources: Alliance (1),  Gene:259252 (1),  Ensembl(GRCz11):ENSDARG00000004111 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb248 Indel Exon 4 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa29373 Point Mutation Unknown Premature Stop ENU
    uab118 Small Deletion Unknown Frameshift, Premature Stop CRISPR
    uab119 Small Deletion Unknown Unknown CRISPR
    umo10 Small Deletion Exon 2 Premature Stop CRISPR
    zf2164 Small Deletion Exon 3 Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-esr1
    1
    CRISPR2-esr1 1
    CRISPR3-esr1 1
    CRISPR4-esr1 2
    CRISPR5-esr1 1
    MO1-esr1 N/A 1
    MO2-esr1 N/A 5
    MO3-esr1 N/A 3
    MO4-esr1 N/A 1
    TALEN1-esr1 1
    DISEASE ASSOCIATED WITH esr1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    breast cancer Alliance Breast cancer, somatic 114480
    migraine Alliance {Migraine, susceptibility to} 157300
    Estrogen resistance 615363
    {Myocardial infarction, susceptibility to} 608446
    DISEASE ASSOCIATED WITH esr1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to estrogen stimulus (more)
    Cellular Component nucleus (more)
    Molecular Function estrogen receptor activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA esr1-202 (1)    Ensembl 3449
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM esr1 No data available
    MARKER RELATIONSHIPS
    esr1 Contained in: [BAC] CH73-109I14 (1), CH73-192G21 (1), CH211-87A14 (1), CH211-147O6 (1)
    esr1 Encodes: [EST] af349412 (1), eu209 (1)
    [cDNA] MGC:193559 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_152959 (1) 3439 nt
    Genomic GenBank:BX936462 196432 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QHN3 (1) 623 aa
    Sequence Information (all 48)
    ORTHOLOGY for esr1 ( Chr: 20 )
    CITATIONS (295)