ZFIN Gene: esr1

ZFIN ID: ZDB-GENE-020806-5

ZFIN ID: ZDB-GENE-020806-5

Gene Name:

estrogen receptor 1

Gene Symbol:

esr1 Nomenclature History

Previous Names:

ER[a] (1), ERalpha (1), NR3A1 (1), zfER[a] (1)

Gene Type:

protein_coding_gene

Location:

Chr: 20 Mapping Details/Browsers

Description:

Exhibits estrogen receptor activity; nuclear receptor activity; and steroid hormone binding activity. Involved in several processes, including cellular response to estrogen stimulus; posterior lateral line neuromast primordium migration; and response to estradiol. Predicted to localize to nucleus. Is expressed in several structures, including diencephalon; head; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); systemic scleroderma; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1).

Genome Resources:

Alliance (1), Gene:259252 (1), Ensembl(GRCz11):ENSDARG00000004111 (1)

GENE EXPRESSION
All Expression Data:	43 figures from 26 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2005 [eu209]
	7 figures (7 images) from Thisse et al., 2008 [af349412]
Wild-type Stages, Structures:	Blastula:512-cell (2.75h-3.0h) to Adult (90d-730d, breeding adult)
	brain caudal tuberal nucleus eye female organism forebrain female organism hindbrain female organism hypophysis female organism midbrain head heart hypophysis intestine lateral hypothalamic nucleus liver male organism forebrain male organism hindbrain male organism midbrain ovary periventricular nucleus rostral parvocellular preoptic nucleus testis unspecified whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
ihb248	Indel	Exon 4	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)
sa29373	Point Mutation	Unknown	Premature Stop	ENU
uab118	Small Deletion	Unknown	Frameshift, Premature Stop	CRISPR
uab119	Small Deletion	Unknown	Unknown	CRISPR
umo10	Small Deletion	Exon 2	Premature Stop	CRISPR
zf2164	Small Deletion	Exon 3	Frameshift, Premature Stop	TALEN

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-esr1		1
CRISPR2-esr1	umo10	1
CRISPR3-esr1	umo10	1
CRISPR4-esr1	uab118 uab119	2
CRISPR5-esr1	ihb248	1
MO1-esr1	N/A	1
MO2-esr1	N/A	5
MO3-esr1	N/A	3
MO4-esr1	N/A	1
TALEN1-esr1	zf2164	1

PHENOTYPE

Data:	12 figures from 4 publications
Observed in:	female organism 11-oxotestosterone female organism estradiol female organism hypophysis liver male organism ovarian follicle vitellogenesis ovarian follicle ovarian follicle stage IV ovary posterior lateral line neuromast primordium migration posterior lateral line primordium sex determination testis whole organism

DISEASE ASSOCIATED WITH esr1 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
breast cancer	Alliance	Breast cancer, somatic	114480
migraine	Alliance	{Migraine, susceptibility to}	157300
		Estrogen resistance	615363
		{Myocardial infarction, susceptibility to}	608446

DISEASE ASSOCIATED WITH esr1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cellular response to estrogen stimulus (more)
Cellular Component	nucleus (more)
Molecular Function	estrogen receptor activity (more)

GO Terms (all 21)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	esr1-202 (1)	3449	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM esr1 No data available

MARKER RELATIONSHIPS

esr1 Contained in:	[BAC] CH73-109I14 (1), CH73-192G21 (1), CH211-87A14 (1), CH211-147O6 (1)
esr1 Encodes:	[EST] af349412 (1), eu209 (1) [cDNA] MGC:193559 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_152959 (1)	3439 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX936462	196432 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A2R8QHN3 (1)	623 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 48)

ORTHOLOGY for esr1 ( Chr: 20 )

CITATIONS (295)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: