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ZIRC
ZFIN ID: ZDB-GENE-020802-5
Gene Name: homogentisate 1,2-dioxygenase
Gene Symbol: hgd    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have homogentisate 1,2-dioxygenase activity. Predicted to be involved in L-phenylalanine catabolic process. Human ortholog(s) of this gene implicated in alkaptonuria. Is expressed in digestive system; fin; median fin fold; pectoral fin bud; and retina. Orthologous to human HGD (homogentisate 1,2-dioxygenase).
Genome Resources: Alliance (1),  Gene:259189 (1),  Ensembl(GRCz11):ENSDARG00000058005 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9565 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hgd HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    alkaptonuria Alliance Alkaptonuria 203500
    DISEASE ASSOCIATED WITH hgd VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process L-phenylalanine catabolic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function dioxygenase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR005708 (1)
  • InterPro:IPR011051 (1)
  • InterPro:IPR014710 (1)
  • Pfam:PF04209 (1)
  • EC:1.13.11.5 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hgd-201 (1)    Ensembl 1637
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hgd No data available
    MARKER RELATIONSHIPS
    hgd Contained in: [BAC] CH211-80N22 (1) (order this), DKEY-162H1 (1) (order this)
    hgd Contains: [STS] unp1247
    hgd Encodes: [EST] IMAGE:6899338 (1) (order this)
    [cDNA] MGC:77584 (1) (order this), MGC:173950 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152966 (1) 1595 bp
    Genomic GenBank:BX470095 (1) 209513 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q7C6 (1) 472 aa
    Sequence Clusters UniGene:3529 (1)
    Sequence Information (all 19)
    ORTHOLOGY for hgd ( Chr: 24 )
    CITATIONS (24)