Gene

malt2

ID
ZDB-GENE-020801-2
Name
MALT paracaspase 2
Symbol
malt2 Nomenclature History
Previous Names
  • malt1
  • malt1a
  • paracaspace (1)
  • pcasp1a
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in lymphoma; non-Hodgkin lymphoma; and primary immunodeficiency disease. Orthologous to human MALT1 (MALT1 paracaspase).
Genome Resources
Note
Hulpiau, et al. (2016) demonstrate that this gene is orthologous to Malt2/Pcasp2 in chicken and turtle, and they suggest that mammals lost MALT2.
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With malt2 Human Ortholog
No data available
Associated With malt2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001309 Peptidase C14, p20 domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR037940 MALT1, death domain
Domain IPR041077 MALT1 immunoglobulin-like domain
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR029030 Caspase-like domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Caspase-like domain superfamily Death-like domain superfamily Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 MALT1, death domain MALT1 immunoglobulin-like domain Peptidase C14, p20 domain
UniProtKB:Q9DDL2 806
UniProtKB:E9QH52 108
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations