Gene

mycn

ID

ZDB-GENE-020711-1

Name

MYCN proto-oncogene, bHLH transcription factor

Symbol

mycn Nomenclature History

Previous Names

N-myc (1)
fb57a02 (1)
nmyc1 (1)
wu:fb57a02 (1)
zgc:85706 (1)
zN-myc (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Is expressed in several structures, including immature eye; nervous system; pectoral fin bud; pharyngeal arch; and pronephric duct. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mycn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Feingold syndrome	Alliance	Feingold syndrome 1	164280
		Megalencephaly-polydactyly syndrome	620748

Associated With mycn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR012682	Transcription regulator Myc, N-terminal
Family	IPR002418	Transcription regulator Myc
Family	IPR050433	Myc family transcription factors
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily