Gene

myhz2

ID

ZDB-GENE-020604-1

Name

myosin, heavy polypeptide 2, fast muscle specific

Symbol

myhz2 Nomenclature History

Previous Names

fmyhc2.1 (1)
myo2hc2 (1)
sb:cb38

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in embryonic skeletal system development; response to activity; and skeletal muscle fiber development. Predicted to localize to myosin complex. Is expressed in fin; musculature system; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in disease of cellular proliferation; distal arthrogryposis type 2A; distal arthrogryposis type 2B1; distal arthrogryposis type 2B3; and distal arthrogryposis type 7. Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH4 (myosin heavy chain 4); and MYH8 (myosin heavy chain 8).

Genome Resources

Note

None

Expression

All Expression Data

31 figures from 21 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

cb38 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myhz2 Human Ortholog

No data available

Associated With myhz2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR001609	Myosin head, motor domain
Domain	IPR002928	Myosin tail
Domain	IPR004009	Myosin, N-terminal, SH3-like
Homologous_superfamily	IPR008989	Myosin S1 fragment, N-terminal
Homologous_superfamily	IPR027401	Myosin IQ motif-containing domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily