Gene

myhz2

ID
ZDB-GENE-020604-1
Name
myosin, heavy polypeptide 2, fast muscle specific
Symbol
myhz2 Nomenclature History
Previous Names
  • fmyhc2.1 (1)
  • myo2hc2 (1)
  • sb:cb38
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in embryonic skeletal system development; response to activity; and skeletal muscle fiber development. Predicted to localize to myosin complex. Is expressed in fin; musculature system; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in disease of cellular proliferation; distal arthrogryposis type 2A; distal arthrogryposis type 2B1; distal arthrogryposis type 2B3; and distal arthrogryposis type 7. Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH4 (myosin heavy chain 4); and MYH8 (myosin heavy chain 8).
Genome Resources
Note
None
Expression
All Expression Data
31 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myhz2 Human Ortholog
No data available
Associated With myhz2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin IQ motif-containing domain superfamily Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q1JPZ0 458
UniProtKB:Q90ZE5 824
UniProtKB:A0JMC2 973
UniProtKB:A5D6S9 886
UniProtKB:Q6IQX1 1935
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations