ZFIN Gene: myhz2

ZFIN ID: ZDB-GENE-020604-1

ZFIN ID: ZDB-GENE-020604-1

Gene Name:

myosin, heavy polypeptide 2, fast muscle specific

Gene Symbol:

myhz2 Nomenclature History

Previous Names:

fmyhc2.1 (1), myo2hc2 (1), sb:cb38

Gene Type:

protein_coding_gene

Location:

Chr: 5 Mapping Details/Browsers

Description:

Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in embryonic skeletal system development; response to activity; and skeletal muscle fiber development. Predicted to localize to myosin complex. Is expressed in fin; musculature system; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in disease of cellular proliferation; distal arthrogryposis type 2A; distal arthrogryposis type 2B1; distal arthrogryposis type 2B3; and distal arthrogryposis type 7. Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH4 (myosin heavy chain 4); and MYH8 (myosin heavy chain 8).

Genome Resources:

Alliance (1), Gene:246275 (1), Ensembl(GRCz11):ENSDARG00000012944 (2)

GENE EXPRESSION
All Expression Data:	30 figures from 20 publications
Directly Submitted Expression Data:	4 figures (4 images) from Thisse et al., 2001 [cb38]
Wild-type Stages, Structures:	Segmentation:5-9 somites (11.66h-14.0h) to Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth)
	caudal fin somite cephalic musculature dorsal oblique extraocular muscle dorsal rectus extraocular musculature fast muscle cell striated muscle myosin thick filament fast muscle cell head muscle hyohyoideus interhyoideus lateral rectus mandibular arch skeleton muscle medial rectus muscle musculature system myotome pectoral fin pectoral fin musculature pharyngeal arch muscle skeletal muscle fast muscle cell skeletal muscle somite fast muscle cell somite sternohyoid deep region sternohyoid trunk posterior region trunk somite trunk unspecified ventral intermandibularis anterior ventral intermandibularis posterior ventral oblique extraocular muscle ventral rectus whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
dmh31	Point Mutation	Unknown	Nonsynonymous	ENU
sa6986	Point Mutation	Unknown	Splice Site	ENU
sa8989	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa10296	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa26505	Point Mutation	Unknown	Premature Stop	ENU
sa26506	Point Mutation	Unknown	Premature Stop	ENU
sa40473	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40474	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40475	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-myhz2	N/A	1

PHENOTYPE

Data:	2 figures from 2 publications
Observed in:	caudal fin muscle cell caudal fin musculature sarcomere muscle cell sarcomere muscle cell notochord whole organism

DISEASE ASSOCIATED WITH myhz2 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH myhz2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	response to activity (more)
Cellular Component	myosin complex (more)
Molecular Function	actin binding (more)

GO Terms (all 10)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	myhz2-202 (1)	5990	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM myhz2

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(myhz2:EGFP)	myhz2	EGFP	Danio rerio	1	1
Tg(myhz2:GFP)	myhz2	GFP	Danio rerio	1	3

MARKER RELATIONSHIPS

myhz2 Contained in:	[BAC] CH211-251M3 (1)
myhz2 Encodes:	[EST] cb38 (order this) [cDNA] MGC:85728 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_152982 (1)	5991 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX511237 (1)	52527 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q6IQX1 (1)	1935 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 22)

ORTHOLOGY for myhz2 ( Chr: 5 )

CITATIONS (75)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: