ZFIN ID: ZDB-GENE-020604-1
Gene Name: myosin, heavy polypeptide 2, fast muscle specific
Gene Symbol: myhz2    Nomenclature History

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Previous Names: fmyhc2.1 (1), myo2hc2 (1), sb:cb38

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in embryonic skeletal system development; response to activity; and skeletal muscle fiber development. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in disease of cellular proliferation; distal arthrogryposis; inclusion body myositis; and multiple pterygium syndrome. Is expressed in fin; musculature system; pharyngeal arch; and trunk. Orthologous to several human genes including MYH1 (myosin heavy chain 1) and MYH4 (myosin heavy chain 4).
Genome Resources: Alliance (1),  Gene:246275 (1),  Ensembl(GRCz11):ENSDARG00000012944 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dmh31 Point Mutation Unknown Nonsynonymous ENU
sa6986 Point Mutation Unknown Splice Site ENU
sa8989 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10296 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26505 Point Mutation Unknown Premature Stop ENU
    sa26506 Point Mutation Unknown Premature Stop ENU
    sa40473 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40474 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40475 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-myhz2 N/A 1
    DISEASE ASSOCIATED WITH myhz2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH myhz2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to activity (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR001609 Myosin head, motor domain
    Domain IPR002928 Myosin tail
    Domain IPR004009 Myosin, N-terminal, SH3-like
    Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
    Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myhz2-202 (1)    Ensembl 5990
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myhz2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(myhz2:EGFP) myhz2 EGFP Danio rerio 1 1
    Tg(myhz2:GFP) myhz2 GFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    myhz2 Contained in: [BAC] CH211-251M3 (1)
    myhz2 Encodes: [EST] cb38 (order this)
    [cDNA] MGC:85728 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152982 (1) 5991 bp
    Genomic GenBank:BX511237 (1) 52527 bp
    Select Tool
    Polypeptide UniProtKB:Q6IQX1 (1) 1935 aa
    Sequence Information (all 22)
    ORTHOLOGY for myhz2 ( Chr: 5 )
    CITATIONS (74)