Gene

gpib

ID

ZDB-GENE-020513-3

Name

glucose-6-phosphate isomerase b

Symbol

gpib Nomenclature History

Previous Names

PGI (1)
pgi-2 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Is expressed in several structures, including blastoderm; blastomere; head; heart; and yolk syncytial layer. Orthologous to human GPI (glucose-6-phosphate isomerase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gpib Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia	Alliance	Hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency	613470

Associated With gpib Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018189	Phosphoglucose isomerase, conserved site
Domain	IPR035476	Phosphoglucose isomerase, SIS domain 1
Domain	IPR035482	Phosphoglucose isomerase, SIS domain 2
Family	IPR001672	Phosphoglucose isomerase (PGI)
Homologous_superfamily	IPR023096	Phosphoglucose isomerase, C-terminal
Homologous_superfamily	IPR046348	SIS domain superfamily