ZFIN ID: ZDB-GENE-020513-3
Gene Name: glucose-6-phosphate isomerase b
Gene Symbol: gpib    Nomenclature History

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Previous Names: PGI (1), pgi-2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to localize to cytosol. Is expressed in several structures, including blastoderm; blastomere; head; heart; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase).
Genome Resources: Alliance (1),  Gene:246095 (1),  Ensembl(GRCz11):ENSDARG00000103826 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35607 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gpib HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital nonspherocytic hemolytic anemia Alliance Hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency 613470
    DISEASE ASSOCIATED WITH gpib VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gluconeogenesis (more)
    Cellular Component cytosol (more)
    Molecular Function glucose-6-phosphate isomerase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gpib-201 (1)    Ensembl 1908
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gpib No data available
    MARKER RELATIONSHIPS
    gpib Contained in: [BAC] CH211-79L17 (1)
    gpib Encodes: [cDNA] MGC:136735 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_144764 (1) 1998 nt
    Genomic GenBank:AL929392 (1) 172427 nt
    Select Tool
    Polypeptide UniProtKB:A8DZE4 (1) 553 aa
    Sequence Information (all 15)
    ORTHOLOGY for gpib ( Chr: 18 )
    CITATIONS (34)