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Gene

invs

ID
ZDB-GENE-020507-2
Name
inversin
Symbol
invs Nomenclature History
Previous Names
  • wu:fe47e11
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable calmodulin binding activity. Acts upstream of or within several processes, including morphogenesis of an epithelium; opsin transport; and urogenital system development. Located in cilium. Used to study ciliopathy. Human ortholog(s) of this gene implicated in nephronophthisis 2. Orthologous to human INVS (inversin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Simons et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With invs Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nephronophthisis 2 Alliance Nephronophthisis 2, infantile 602088
Associated With invs Via Experimental Models
Human Disease Fish Conditions Citations
ciliopathy WT + MO3-invs control Tobin et al., 2008
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR020683 Ankyrin repeat-containing domain
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily IQ motif, EF-hand binding site
UniProtKB:B3DGU0 1025
UniProtKB:A2CF23 1025
UniProtKB:Q8UVC1 1021
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations