ZFIN ID: ZDB-GENE-020506-1
Gene Name: c-ros oncogene 1 , receptor tyrosine kinase
Gene Symbol: ros1    Nomenclature History

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Previous Name: c-ros (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including positive regulation of kinase activity; regulation of TOR signaling; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to integral component of plasma membrane and receptor complex. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase).
Genome Resources: Alliance (1),  Gene:245951 (1),  Ensembl(GRCz11):ENSDARG00000087197 (2)
GENE EXPRESSION
All Expression Data: Fig. 3 from Challa et al., 2013
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013035Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8890 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11486 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45597 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ros1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ros1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein phosphorylation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ros1-201 (1)    Ensembl 4056
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ros1 No data available
    MARKER RELATIONSHIPS
    ros1 Contained in: [BAC] CH211-270G19 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_689237 (1) 4933 nt
    Genomic GenBank:BX276081 (1) 130240 nt
    Select Tool
    Polypeptide UniProtKB:F1QMJ7 (1) 1289 aa
    Sequence Information (all 17)
    ORTHOLOGY for ros1 ( Chr: 17 )
    CITATIONS (22)