ZFIN ID: ZDB-GENE-020503-4
Gene Name: insulin receptor b
Gene Symbol: insrb
Sequence Ontology ID : SO:0000704

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Previous Names: IRb (1), sb:eu666, si:dkey-6n3.1

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(Including Attributions)
Location: Chr: 22 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 12 figures from 11 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu666]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014143Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014144Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028387Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028388Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6697 Point Mutation Unknown Premature Stop ENU
    sa16909 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32383 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • xu0422Gt Transgenic Insertion Unknown Unknown DNA
    Targeting reagents:
    PHENOTYPE
    Data: Fig. 6 from Toyoshima et al., 2008
    Observed in:
    DISEASE ASSOCIATED WITH insrb HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Donohue syndrome Leprechaunism 246200
    familial hyperinsulinemic hypoglycemia 5 Hyperinsulinemic hypoglycemia, familial, 5 609968
    hyperinsulinemic hypoglycemia Hyperinsulinemic hypoglycemia, familial, 5 609968
    Diabetes mellitus, insulin-resistant, with acanthosis nigricans 610549
    Rabson-Mendenhall syndrome 262190
    DISEASE ASSOCIATED WITH insrb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000494 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002011 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR006211 (1)
  • InterPro:IPR006212 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016246 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR028792 (1)
  • InterPro:IPR036116 (1)
  • InterPro:IPR036941 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00239 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF00757 (1)
  • Pfam:PF01030 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA insrb-001 (1) 5644
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM insrb No data available
    MARKER RELATIONSHIPS
    insrbContained in: [BAC] DKEY-6N3 (1) (order this), DKEY-38O13 (1) (order this)
    insrbEncodes: [EST] eu666 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001123229 (1) 4047bp
    Genomic GenBank:BX666064 (1) 156234bp
    Select Tool
    Polypeptide UniProtKB:Q1LVG4 (1) 1348aa
    Sequence Clusters UniGene:88572 (1)
    Sequence Information (all 17)
    OTHER insrb GENE PAGES
  • Alliance (1)
  • Gene:245700 (1)
  • VEGA:OTTDARG00000009492 (1)
  • Ensembl(GRCz11):ENSDARG00000071524 (2)
  • ORTHOLOGY for insrb (Chr: 22)
    CITATIONS (54)