ZFIN ID: ZDB-GENE-020503-4
Gene Name: insulin receptor b
Gene Symbol: insrb    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: IRb (1), sb:eu666, si:dkey-6n3.1

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have insulin receptor substrate binding activity and insulin-activated receptor activity. Involved in chordate embryonic development; developmental growth; and glycolytic process. Predicted to localize to axon and insulin receptor complex. Is expressed in several structures, including endoderm; fertilized egg; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).
Genome Resources: Alliance (1),  Gene:245700 (1),  Ensembl(GRCz11):ENSDARG00000071524 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb358 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • la014143Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la014144Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028387Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028388Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6697 Point Mutation Unknown Premature Stop ENU
    sa16909 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32383 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • xu0422Gt Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-insrb
    1
    CRISPR2-insrb
    1
    CRISPR3-insrb
    1
    MO1-insrb N/A 2
    MO2-insrb N/A 2
    TALEN1-insrb
    1
    TALEN2-insrb
    1
    TALEN3-insrb
    1
    TALEN4-insrb
    1
    TALEN5-insrb
    1
    TALEN6-insrb
    1
    DISEASE ASSOCIATED WITH insrb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Donohue syndrome Alliance Leprechaunism 246200
    familial hyperinsulinemic hypoglycemia 5 Alliance Hyperinsulinemic hypoglycemia, familial, 5 609968
    Diabetes mellitus, insulin-resistant, with acanthosis nigricans 610549
    Rabson-Mendenhall syndrome 262190
    DISEASE ASSOCIATED WITH insrb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA insrb-201 (1)    Ensembl 5644
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM insrb No data available
    MARKER RELATIONSHIPS
    insrb Contained in: [BAC] DKEY-6N3 (1) (order this), DKEY-38O13 (1) (order this)
    insrb Encodes: [EST] eu666 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001123229 (1) 4047 nt
    Genomic GenBank:BX666064 (1) 156234 nt
    Select Tool
    Polypeptide UniProtKB:Q1LVG4 (1) 1348 aa
    Sequence Information (all 16)
    ORTHOLOGY for insrb ( Chr: 22 )
    CITATIONS (65)