ZFIN ID: ZDB-GENE-020503-3
Gene Name: insulin receptor a
Gene Symbol: insra    Nomenclature History

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Previous Name: IRa (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have insulin receptor substrate binding activity and insulin-activated receptor activity. Involved in several processes, including chordate embryonic development; gluconeogenesis; and glycolytic process. Predicted to localize to axon and insulin receptor complex. Is expressed in several structures, including fertilized egg; immature eye; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).
Genome Resources: Alliance (1),  Gene:245699 (1),  Ensembl(GRCz11):ENSDARG00000011948 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb357 Indel Exon 1 Frameshift, Premature Stop TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • la014939Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la023659Tg Transgenic Insertion Unknown Unknown DNA
    psi101 Point Mutation Exon 3 Missense CRISPR
    sa1682 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6016 Point Mutation Unknown Premature Stop ENU
    sa32968 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-insra 2
    CRISPR2-insra
    1
    CRISPR3-insra
    1
    MO1-insra N/A 2
    MO2-insra N/A 2
    TALEN1-insra
    1
    TALEN2-insra
    1
    TALEN3-insra
    1
    TALEN4-insra
    1
    TALEN5-insra
    1
    TALEN6-insra
    1
    DISEASE ASSOCIATED WITH insra HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Donohue syndrome Alliance Leprechaunism 246200
    familial hyperinsulinemic hypoglycemia 5 Alliance Hyperinsulinemic hypoglycemia, familial, 5 609968
    Diabetes mellitus, insulin-resistant, with acanthosis nigricans 610549
    Rabson-Mendenhall syndrome 262190
    DISEASE ASSOCIATED WITH insra VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gluconeogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 31)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA insra-201 (1)    Ensembl 6191
    ncRNA insra-002 (1)    Ensembl 784
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM insra No data available
    MARKER RELATIONSHIPS
    insra Contained in: [BAC] DKEY-57K2 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001142672 (1) 6219 nt
    Genomic GenBank:BX539340 (1) 234470 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B7SNG4 (1) 1353 aa
    Sequence Information (all 16)
    ORTHOLOGY for insra ( Chr: 2 )
    CITATIONS (68)