Gene

insra

ID
ZDB-GENE-020503-3
Name
insulin receptor a
Symbol
insra Nomenclature History
Previous Names
  • IRa (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have insulin receptor substrate binding activity and insulin-activated receptor activity. Involved in several processes, including chordate embryonic development; gluconeogenesis; and glycolytic process. Predicted to localize to axon and insulin receptor complex. Is expressed in several structures, including fertilized egg; immature eye; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With insra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Donohue syndrome Alliance Leprechaunism 246200
familial hyperinsulinemic hypoglycemia 5 Alliance Hyperinsulinemic hypoglycemia, familial, 5 609968
Diabetes mellitus, insulin-resistant, with acanthosis nigricans 610549
Rabson-Mendenhall syndrome 262190
Associated With insra Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Domain IPR000494 Receptor L-domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003961 Fibronectin type III
Domain IPR006211 Furin-like cysteine-rich domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR040969 Insulin receptor, trans-membrane domain
Family IPR016246 Tyrosine-protein kinase, insulin-like receptor
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036941 Receptor L-domain superfamily
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Furin-like cysteine-rich domain Furin-like repeat Growth factor receptor cysteine-rich domain superfamily Immunoglobulin-like fold Insulin receptor, trans-membrane domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor L-domain Receptor L-domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, insulin-like receptor Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:F1QNX5 1353
UniProtKB:B8PR94 112
UniProtKB:B7SNG4 1353
UniProtKB:Q8QGM9 133
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations