ZFIN ID: ZDB-GENE-020423-5 |
Gene Name: | follicle stimulating hormone receptor | ||||||
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Gene Symbol: | fshr Nomenclature History | ||||||
Previous Names: | gonadotropic hormone I (1), GTHR-I (1), zfGTHR-I | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Chr: 12 Mapping Details/Browsers | ||||||
Description: | Exhibits follicle-stimulating hormone receptor activity. Involved in male gonad development; ovarian follicle development; and spermatogenesis. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Is expressed in Leydig cell; gonad; and kidney. Orthologous to human FSHR (follicle stimulating hormone receptor). | ||||||
Genome Resources: | Alliance (1), Gene:195820 (1), Ensembl(GRCz11):ENSDARG00000071494 (1) |
All Expression Data: | 13 figures from 10 publications |
Directly Submitted Expression Data: | 1 figure (1 image) from Thisse et al., 2005 [eu86] |
Wild-type Stages, Structures: | Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth) to Adult (90d-730d, breeding adult) |
Curated Microarray Expression: | GEO (1) |
Allele | Type | Localization | Consequence | Mutagen | Suppliers |
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sa13419 | Point Mutation | Unknown | Splice Site | ENU |
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sa42035 | Point Mutation | Unknown | Splice Site | ENU |
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umo3 | Small Deletion | Unknown | Frameshift | TALEN | |
zf687 | Small Deletion | Exon 2 | Frameshift, Premature Stop | TALEN |
Targeting Reagent | Created Alleles | Publications |
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TALEN1-fshr | 1 | |
TALEN2-fshr | 1 |
Data: | 7 figures from 2 publications |
Observed in: |
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
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ovarian dysgenesis 1 | Alliance | Ovarian dysgenesis 1 | 233300 |
ovarian hyperstimulation syndrome | Alliance | Ovarian hyperstimulation syndrome | 608115 |
Ovarian response to FSH stimulation | 276400 |
Ontology | GO Term |
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Biological Process | female gonad development (more) |
Cellular Component | integral component of membrane (more) |
Molecular Function | follicle-stimulating hormone receptor activity (more) |
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Type | Name | Length (nt) | Analysis | |
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mRNA |
fshr-201
(1)
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2543 |
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Browsers: UCSC, NCBI, Ensembl, ZFIN |
fshr Contained in: | [BAC] DKEY-25M3 (1) (order this) |
fshr Encodes: | [EST] eu86 (1) |
Type | Accession # | Length (bp/aa) | Analysis |
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RNA | RefSeq:NM_001001812 (1) | 2543 bp |
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Genomic | GenBank:BX677665 (1) | 136144 bp | |
Polypeptide | UniProtKB:A0A2R8RSR3 (1) | 668 aa |
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Sequence Clusters | UniGene:80713 (1) |