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Gene

fshr

ID
ZDB-GENE-020423-5
Name
follicle stimulating hormone receptor
Symbol
fshr Nomenclature History
Previous Names
  • gonadotropic hormone I (1)
  • GTHR-I (1)
  • zfGTHR-I
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Enables follicle-stimulating hormone receptor activity. Acts upstream of or within male gonad development; ovarian follicle development; and spermatogenesis. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in Leydig cell; female organism; gonad; and kidney. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Orthologous to human FSHR (follicle stimulating hormone receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fshr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ovarian dysgenesis 1 Alliance Ovarian dysgenesis 1 233300
ovarian hyperstimulation syndrome Alliance Ovarian hyperstimulation syndrome 608115
Ovarian response to FSH stimulation 276400
Associated With fshr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR002131 Glycoprotein hormone receptor family
Family IPR002272 Follicle stimulating hormone receptor
Family IPR002274 Thyrotropin receptor
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR026906 BspA type Leucine rich repeat region
Domain Details Per Protein
Protein Length BspA type Leucine rich repeat region Follicle stimulating hormone receptor Glycoprotein hormone receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Leucine-rich repeat Leucine-rich repeat domain superfamily Thyrotropin receptor
UniProtKB:F1R4X9 668
UniProtKB:A0A2R8RSR3 668
UniProtKB:Q6TCF9 668
UniProtKB:Q7ZZC0 668
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations