ZFIN ID: ZDB-GENE-020423-5
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Gene Name: follicle stimulating hormone receptor
Gene Symbol: fshr    Nomenclature History

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Previous Names: gonadotropic hormone I (1), GTHR-I (1), zfGTHR-I

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits follicle-stimulating hormone receptor activity. Involved in male gonad development; ovarian follicle development; and spermatogenesis. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Is expressed in Leydig cell; gonad; and kidney. Orthologous to human FSHR (follicle stimulating hormone receptor).
Genome Resources: Alliance (1),  Gene:195820 (1),  Ensembl(GRCz11):ENSDARG00000071494 (1)
GENE EXPRESSION
All Expression Data: 14 figures from 11 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu86]
Wild-type Stages, Structures: Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13419 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42035 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • umo3 Small Deletion Unknown Frameshift TALEN
    zf687 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-fshr 1
    TALEN2-fshr 1
    PHENOTYPE
    Data: 7 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH fshr HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ovarian dysgenesis 1 Alliance Ovarian dysgenesis 1 233300
    ovarian hyperstimulation syndrome Alliance Ovarian hyperstimulation syndrome 608115
    Ovarian response to FSH stimulation 276400
    DISEASE ASSOCIATED WITH fshr VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process female gonad development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function follicle-stimulating hormone receptor activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000276 G protein-coupled receptor, rhodopsin-like
    Repeat IPR001611 Leucine-rich repeat
    Family IPR002131 Glycoprotein hormone receptor family
    Family IPR002272 Follicle stimulating hormone receptor
    Family IPR002274 Thyrotropin receptor
    Domain IPR017452 GPCR, rhodopsin-like, 7TM
    Repeat IPR026906 BspA type Leucine rich repeat region
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fshr-201 (1)    Ensembl 2543
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fshr No data available
    MARKER RELATIONSHIPS
    fshr Contained in: [BAC] DKEY-25M3 (1) (order this)
    fshr Encodes: [EST] eu86 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001001812 (1) 2543 bp
    Select Tool
    Genomic GenBank:BX677665 (1) 136144 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8RSR3 (1) 668 aa
    Select Tool
    Sequence Information (all 12)
    ORTHOLOGY for fshr ( Chr: 12 )
    CITATIONS (106)