Gene

fshr

ID

ZDB-GENE-020423-5

Name

follicle stimulating hormone receptor

Symbol

fshr Nomenclature History

Previous Names

gonadotropic hormone I (1)
GTHR-I (1)
zfGTHR-I

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Exhibits follicle-stimulating hormone receptor activity. Involved in male gonad development; ovarian follicle development; and spermatogenesis. Predicted to localize to integral component of plasma membrane. Is expressed in Leydig cell; female organism; gonad; and kidney. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Orthologous to human FSHR (follicle stimulating hormone receptor).

Genome Resources

Note

None

Expression

All Expression Data

17 figures from 14 publications

Cross-Species Comparison

High Throughput Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fshr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
ovarian dysgenesis 1	Alliance	Ovarian dysgenesis 1	233300
ovarian hyperstimulation syndrome	Alliance	Ovarian hyperstimulation syndrome	608115
		Ovarian response to FSH stimulation	276400

Associated With fshr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR002131	Glycoprotein hormone receptor family
Family	IPR002272	Follicle stimulating hormone receptor
Family	IPR002274	Thyrotropin receptor
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR026906	BspA type Leucine rich repeat region