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ZIRC
ZFIN ID: ZDB-GENE-020423-5
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Gene Name: follicle stimulating hormone receptor
Gene Symbol: fshr    Nomenclature History

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Previous Names: gonadotropic hormone I (1), GTHR-I (1), zfGTHR-I

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits follicle-stimulating hormone receptor activity. Involved in male gonad development; ovarian follicle development; and spermatogenesis. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Is expressed in Leydig cell; gonad; and kidney. Orthologous to human FSHR (follicle stimulating hormone receptor).
Genome Resources: Alliance (1),  Gene:195820 (1),  Ensembl(GRCz11):ENSDARG00000071494 (1)
GENE EXPRESSION
All Expression Data: 13 figures from 10 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu86]
Wild-type Stages, Structures: Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13419 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42035 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • umo3 Small Deletion Unknown Frameshift TALEN
    zf687 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-fshr 1
    TALEN2-fshr 1
    PHENOTYPE
    Data: 7 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH fshr HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ovarian dysgenesis 1 Alliance Ovarian dysgenesis 1 233300
    ovarian hyperstimulation syndrome Alliance Ovarian hyperstimulation syndrome 608115
    Ovarian response to FSH stimulation 276400
    DISEASE ASSOCIATED WITH fshr VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process female gonad development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function follicle-stimulating hormone receptor activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000276 (1)
  • InterPro:IPR001611 (1)
  • InterPro:IPR002131 (1)
  • InterPro:IPR002272 (1)
  • InterPro:IPR002274 (1)
  • InterPro:IPR017452 (1)
  • InterPro:IPR026906 (1)
  • InterPro:IPR032675 (1)
  • PROSITE:PS00237 (1)
  • PROSITE:PS50262 (1)
  • Pfam:PF00001 (1)
  • Pfam:PF13306 (1)
  • Pfam:PF13855 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fshr-201 (1)    Ensembl 2543
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fshr No data available
    MARKER RELATIONSHIPS
    fshr Contained in: [BAC] DKEY-25M3 (1) (order this)
    fshr Encodes: [EST] eu86 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001001812 (1) 2543 bp
    Select Tool
    Genomic GenBank:BX677665 (1) 136144 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8RSR3 (1) 668 aa
    Select Tool
    Sequence Clusters UniGene:80713 (1)
    Sequence Information (all 13)
    ORTHOLOGY for fshr ( Chr: 12 )
    CITATIONS (99)