Gene
fshr
- ID
- ZDB-GENE-020423-5
- Name
- follicle stimulating hormone receptor
- Symbol
- fshr Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables follicle-stimulating hormone receptor activity. Acts upstream of or within follicle-stimulating hormone signaling pathway; male gonad development; and spermatogenesis. Predicted to be located in basolateral plasma membrane. Is expressed in Leydig cell; female organism; gonad; and kidney. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Orthologous to human FSHR (follicle stimulating hormone receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu86 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ovarian dysgenesis 1 | Alliance | Ovarian dysgenesis 1 | 233300 |
| ovarian hyperstimulation syndrome | Alliance | Ovarian hyperstimulation syndrome | 608115 |
| Ovarian response to FSH stimulation | 276400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR017452 | GPCR, rhodopsin-like, 7TM |
| Family | IPR000276 | G protein-coupled receptor, rhodopsin-like |
| Family | IPR002131 | Glycoprotein hormone receptor family |
| Family | IPR002272 | Follicle stimulating hormone receptor |
| Family | IPR002274 | Thyrotropin receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR026906 | BspA type Leucine rich repeat region |
Domain Details Per Protein
| Protein | Length | BspA type Leucine rich repeat region | Follicle stimulating hormone receptor | Glycoprotein hormone receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Thyrotropin receptor |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6TCF9
|
668 | ||||||||
|
UniProtKB:A0A2R8RSR3
|
668 | ||||||||
|
UniProtKB:F1R4X9
|
668 | ||||||||
|
UniProtKB:Q7ZZC0
|
668 |
Interactions and Pathways
No data available
Plasmids
No data available