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ZIRC
ZFIN ID: ZDB-GENE-020419-3
Gene Name: beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
Gene Symbol: b3gat3    Nomenclature History

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Previous Names: beta-1,3-glucuronyltransferase 3, CHUNP6865, fe01c06, wu:fe01c06, zgc:112070

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Involved in cartilage development; extracellular matrix organization; and proteoglycan biosynthetic process. Predicted to localize to the Golgi membrane. Human ortholog(s) of this gene implicated in Larsen-like syndrome B3GAT3 type. Orthologous to human B3GAT3 (beta-1,3-glucuronyltransferase 3).
Genome Resources: Alliance (1),  Gene:192334 (1),  Ensembl(GRCz11):ENSDARG00000001939 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:112070]
  1 figure (1 image) from Thisse et al., 2005 [eu280]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi307Tg Transgenic Insertion 5' UTR Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi4205Tg Transgenic Insertion Intron 1 Unknown DNA
    sa17161 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26951 Point Mutation Unknown Premature Stop ENU
    DISEASE ASSOCIATED WITH b3gat3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Larsen-like syndrome B3GAT3 type Alliance Multiple joint dislocations, short stature, craniofacial dysmorphism, with or without congenital heart defects 245600
    DISEASE ASSOCIATED WITH b3gat3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development (more)
    Cellular Component Golgi apparatus (more)
    Molecular Function galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR005027 (1)
  • InterPro:IPR029044 (1)
  • Pfam:PF03360 (1)
  • EC:2.4.1.135 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA b3gat3-202 (1)    Ensembl 3739
    ncRNA b3gat3-002 (1)    Ensembl 879
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM b3gat3 No data available
    MARKER RELATIONSHIPS
    b3gat3 Contained in: [BAC] DKEY-23I12 (1) (order this), DKEY-269E10 (1) (order this)
    [Fosmid] CH1073-129B4 (1) (order this)
    b3gat3 Encodes: [BAC END] zk19k20
    [EST] eu280 (1), fe01c06
    [cDNA] MGC:112070 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001015059 (1) 1598 bp
    Genomic GenBank:AL954715 (1) 195884 bp
    Select Tool
    Polypeptide UniProtKB:F8W289 (1) 330 aa
    Sequence Clusters UniGene:80627 (1)
    Sequence Information (all 24)
    ORTHOLOGY for b3gat3 ( Chr: 7 )
    CITATIONS (39)