ZFIN ID: ZDB-GENE-020125-3
Gene Name: glutamate receptor, ionotropic, AMPA 2a
Gene Symbol: gria2a    Nomenclature History

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Previous Names: glur2a (1), gria2.1, zfGRIA2[a] (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have AMPA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including embryonic cranial skeleton morphogenesis; mechanosensory lateral line system development; and neural crest cell development. Predicted to localize to AMPA glutamate receptor complex; dendritic spine; and postsynaptic density membrane. Is expressed in nervous system. Orthologous to human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2).
Genome Resources: Alliance (1),  Gene:170450 (1),  Ensembl(GRCz11):ENSDARG00000070173 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8383 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12891 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gria2a N/A 1
    DISEASE ASSOCIATED WITH gria2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with language impairment and behavioral abnormalities 618917
    DISEASE ASSOCIATED WITH gria2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior lateral line development (more)
    Cellular Component cell junction (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gria2a-201 (1)    Ensembl 1044
    gria2a-202 (1)    Ensembl 3334
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gria2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(myo6b:gria2a-tmie-2a-nls-mcherry) myo6b 2Agria2amCherryNLStmie Danio rerio 1 1
    tg(myo6b:gria2a-tmie-egfp) myo6b EGFPgria2atmie Danio rerio 1 1
    MARKER RELATIONSHIPS
    gria2a Contained in: [BAC] CH73-61K13 (1)
    gria2a Encodes: [EST] eu675 (1)
    [cDNA] MGC:194037 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131894 (1) 2870 nt
    Genomic GenBank:CR925878 (1) 364807 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4ING5 (1) 903 aa
    Sequence Information (all 30)
    ORTHOLOGY for gria2a ( Chr: 1 )
    CITATIONS (35)