Gene

s1pr2

ID
ZDB-GENE-020123-2
Name
sphingosine-1-phosphate receptor 2
Symbol
s1pr2 Nomenclature History
Previous Names
  • S1P2
  • edg5 (1)
  • mil (1)
  • miles apart
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have sphingosine-1-phosphate receptor activity. Involved in several processes, including embryonic morphogenesis; sensory organ development; and sphingosine-1-phosphate receptor signaling pathway. Predicted to localize to cytoplasm and plasma membrane. Is expressed in several structures, including cardiovascular system; midbrain hindbrain boundary neural rod; midbrain hindbrain boundary neural tube; nervous system; and pleuroperitoneal region. Used to study carcinoma. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2).
Genome Resources
Note
None
Expression
All Expression Data
16 figures from 11 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
44 figures from 24 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With s1pr2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 68 Alliance Deafness, autosomal recessive 68 610419
Associated With s1pr2 Via Experimental Models
Human Disease Fish Conditions Citations
carcinoma s1pr2m93/m93 standard conditions Gu et al., 2015
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR004061 Sphingosine 1-phosphate receptor
Family IPR004063 EDG-5 sphingosine 1-phosphate receptor
Domain Details Per Protein
Protein Length EDG-5 sphingosine 1-phosphate receptor GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Sphingosine 1-phosphate receptor
UniProtKB:Q9I8K8 370
UniProtKB:F6KZJ3 30
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations