ZFIN ID: ZDB-GENE-020107-2
Gene Name: protein tyrosine phosphatase receptor type Fa
Gene Symbol: ptprfa    Nomenclature History

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Previous Names: LAR (1), ptprf, zf-LAR (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have protein tyrosine phosphatase activity. Involved in sensory neuron axon guidance. Predicted to localize to integral component of membrane. Is expressed in nervous system; pectoral fin; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine phosphatase receptor type F).
Genome Resources: Alliance (1),  Gene:140819 (1),  Ensembl(GRCz11):ENSDARG00000103479 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a316 Complex Unknown Unknown CRISPR
la025484Tg Transgenic Insertion Unknown Unknown DNA
la025487Tg Transgenic Insertion Unknown Unknown DNA
sa10718 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10963 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18650 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20608 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20609 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ptprfa 1
    CRISPR2-ptprfa 1
    CRISPR3-ptprfa 1
    CRISPR4-ptprfa 1
    CRISPR5-ptprfa
    1
    MO1-ptprfa N/A 2
    MO2-ptprfa N/A 1
    DISEASE ASSOCIATED WITH ptprfa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Breasts and/or nipples, aplasia or hypoplasia of, 2 616001
    DISEASE ASSOCIATED WITH ptprfa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sensory neuron axon guidance (more)
    Cellular Component integral component of membrane (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ptprfa-202 (1)    Ensembl 4041
    ncRNA ptprfa-002 (1)    Ensembl 747
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ptprfa No data available
    MARKER RELATIONSHIPS
    ptprfa Contained in: [BAC] CH211-215F22 (1), CH211-236E24 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001311348 (1)
    Genomic GenBank:BX119315 (1) 210930 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0H2UKT5 (1) 1914 aa
    Sequence Information (all 68)
    ORTHOLOGY for ptprfa ( Chr: 6 )
    CITATIONS (28)