Gene

ptprfa

ID
ZDB-GENE-020107-2
Name
protein tyrosine phosphatase receptor type Fa
Symbol
ptprfa Nomenclature History
Previous Names
  • LAR (1)
  • ptprf
  • zf-LAR (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have protein tyrosine phosphatase activity. Involved in sensory neuron axon guidance. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in hyperinsulinism. Is expressed in nervous system; pectoral fin; pharyngeal arch; and somite. Orthologous to human PTPRF (protein tyrosine phosphatase receptor type F).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptprfa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Breasts and/or nipples, aplasia or hypoplasia of, 2 616001
Associated With ptprfa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR041201 PTPRJ, transmembrane domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like PTPRJ, transmembrane domain
UniProtKB:A0A2R8RIG6 1897
UniProtKB:H9CWQ3 1792
UniProtKB:A0A2R8QFD2 1893
UniProtKB:H9CWQ2 1894
UniProtKB:A0A0H2UKT5 1914
UniProtKB:Q90YJ5 508
UniProtKB:A0A2R8QS03 1791
UniProtKB:F1QLM9 1186
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations